Genetic Epidemiology of Youth Conduct Problems

青少年行为问题的遗传流行病学

• 批准号: 6712701
• 负责人: Benjamin B Lahey
• 金额: $ 40.66万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6712701
• 关键词: academic achievement; adolescence (12-20); age at pregnancy; behavioral /social science research tag; behavioral genetics; conduct disorder; gender difference; gene environment interaction; human data; juvenile delinquency; longitudinal human study; mental health epidemiology; middle childhood (6-11); smoking; socioeconomics; teratogens; urban area

DESCRIPTION (provided by applicant): Youth conduct problems are a serious public health concern, but little progress has been made in understanding their causes. This proposal addresses the genetic epidemiology of youth conduct problems to advance knowledge of their causes. We propose to analyze data from the National Longitudinal Study of Youth, which is a nationally-representative sample of 14-21 year olds first interviewed in 1979 (NLSY79). The NLSY79 includes 4,926 females who are now 37-45 years old. Since 1986, assessments have been conducted of all offspring of these women (Children of NLSY79 Study). Longitudinal data are now available on child conduct problems from ages 4 through 11 years for 5,122 offspring and on delinquent behavior through adolescence for 2,590 offspring. Because the participants are both vertically related (mother and offspring) and horizontally related (full siblings, half-siblings, etc.), their kinship links allow us to use behavior genetic methods to study genetic and environmental influences on youth conduct problems. We will test hypotheses derived from a causal model of the origins of conduct problems that integrates hypotheses from social learning theory, developmental theory, and behavior genetics. Our model shares T. E. Moffitt's assertion that the causes of adolescent delinquency are different for youth who follow different developmental pathways. We will provide the first strong test of this fundamental hypothesis by determining if genetic and environmental influences on adolescent delinquency vary as a function of the youth's level of conduct problems during childhood. We will examine sex differences in the development of conduct problems and test for possible sex differences in causal influences. Behavior genetic analyses typical treat environmental influences as anonymous, but we will estimate the extent to which a number of maternal, family, and community variables, which are important to both scientific theory and public policy, are causally related to youth conduct problems through genetic and environmental correlations. These include maternal age at first birth, maternal smoking during pregnancy, family socioeconomic status, neighborhood socioeconomic status, neighborhood social disorganization, and urbanicity.

描述（由申请人提供）： 青年行为问题是一个严重的公共卫生问题，但是在理解其原因方面几乎没有取得进展。该提议探讨了青年的遗传流行病学，以提高其原因知识。我们建议分析全国青年纵向研究的数据，这是1979年首次接受采访的14-21岁年轻人的全国代表性样本（NLSY79）。 NLSY79包括4,926名现年37-45岁的女性。自1986年以来，已经对这些妇女的所有后代进行了评估（NLSY79研究的孩子）。现在，可以在5,122个后代和通过青春期进行2,590个后代，从4至11岁的儿童行为问题获得纵向数据。由于参与者既垂直相关（母亲和后代），又是水平相关的（完整的兄弟姐妹，半兄弟姐妹等），因此他们的亲属关系使我们能够使用行为遗传方法来研究遗传和环境对青年行为问题的影响。我们将检验从行为问题起源的因果模型中得出的假设，该模型将社会学习理论，发展理论和行为遗传学的假设整合在一起。我们的模型分享了T. E. Moffitt的断言，即遵循不同发展途径的年轻人，青少年犯罪的原因有所不同。我们将通过确定遗传和环境对青少年犯罪的影响是否随着年轻人的水平而变化，从 在童年时期进行问题。我们将研究行为问题发展的性别差异，并测试因果影响的可能性差异。行为遗传分析将典型的环境影响视为匿名，但我们将估计许多母亲，家庭和社区变量在多大程度上对科学理论和公共政策都很重要，这与青年人通过遗传和环境相关性而有因果关系。其中包括孕产妇在初生时期，怀孕期间的孕产妇吸烟，家庭社会经济地位，社区社会经济地位，社区社会混乱和城市化。