Temperamental Low PE in Preschoolers and Depression Risk

学龄前儿童的气质性低体育水平与抑郁风险

• 批准号: 6821558
• 负责人: Daniel N Klein
• 金额: $ 67.57万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6821558
• 关键词: behavioral /social science research tag; case history; child behavior disorders; child mental disorders; clinical research; depression; disease /disorder onset; disease /disorder proneness /risk; electroencephalography; human subject; longitudinal human study; mood disorders; parent offspring interaction; pathologic process; patient oriented research; preschool child (1-5); reinforcer

DESCRIPTION (provided by applicant): Little is known about the precursors and early manifestations of depression. Recent theoretical and empirical work on temperament and mood disorders in adults and children has converged in suggesting that temperamental low positive emotionality (PE) may be a precursor of subsequent depressive disorders. We seek to begin to test this hypothesis by assessing temperament in a large community sample of 3-year old children, examining the relationship between low PE and two better established risk factors for depression, and investigating the stability of PE over a two-year period. Seven hundred and twenty subjects will complete laboratory assessments of temperament, and 396 will be selected for further study, including laboratory assessments of EEG and parent-child interactions; a battery of interview and rating scale measures of temperament and psychopathology in the children and their parents; and a follow-up evaluation atage 5. The project has six specific aims: (1) examine the structure of PE, parse its core components, and distinguish it from the near-neighbor construct of behavioral inhibition (BI); (2) test hypothesized associations between low PE and two other markers of risk for depression: maternal history of mood disorders and asymmetries in EEG activity (decreased left frontal and right parietal activity); (3) investigate the specificity of the low PE-depression relationship by determining whether child low PE is related to non-mood disorders in parents and EEG asymmetries that have been implicated in some forms of anxiety disorders (increased right frontal and right parietal activity) and exploring whether other temperament variables, such as BI, are also associated with a parental history of mood disorders and decreased left frontal and right parietal EEG activity; (4) evaluate the stability of low PE between the ages of 3 and 5, and examine its relationship to BI over time; (5) identify factors that might moderate the developmental trajectory of low PE (and ultimately the development of depression), such as other temperament variables, parental mood disorders, and parenting behavior; and (6) build the foundation for a long-term study that follows the sample into adolescence/young adulthood in order to determine whether low PE at age 3 predicts the subsequent onset of depression.

描述（由申请人提供）：关于抑郁症的前体和早期表现知之甚少。关于成人和儿童气质和情绪障碍的最新理论和经验工作融合表明气质低积极的情绪（PE）可能是随后抑郁症的前体。我们试图通过评估3岁儿童的大型社区样本中的气质来开始检验这一假设，研究低PE与两个更好的抑郁症风险因素之间的关系，并在两年期间研究PE的稳定性。 720名受试者将完成对气质的实验室评估，并将选择396个受试者进行进一步研究，包括对脑电图和亲子相互作用的实验室评估；儿童及其父母的气质和心理病理学的一系列面试和评级量表；和后续评估ATAGE 5。该项目具有六个具体的目的：（1）检查PE的结构，解析其核心成分，并将其与行为抑制的近邻居结构（BI）区分开； （2）测试低PE与其他两个抑郁症风险标志之间的假设关联：情绪障碍的母亲病史和脑电图活性的不对称史（左额叶和右顶点活动降低）； （3）通过确定儿童低PE是否与与某些形式的焦虑症相关的父母和脑电图不对称性的非食物疾病有关（右额叶和右边的顶层活动增加），并探索其他气体变量（例如BI）是否与属于情绪疾病的其他疾病相关，并探索左侧的室内和右侧的parietal retect; （4）评估3至5岁之间低PE的稳定性，并随着时间的推移检查其与BI的关系； （5）确定可能调节低PE的发育轨迹（以及最终抑郁症的发展）的因素，例如其他气质变量，父母情绪障碍和育儿行为； （6）为长期研究建立基础，该研究将样本进入青春期/年轻成年，以确定3岁时低的PE是否可以预测随后的抑郁症的发作。