Temperamental Low PE in Preschoolers and Depression Risk

学龄前儿童的气质性低体育水平与抑郁风险

• 批准号: 6821558
• 负责人: Daniel N Klein
• 金额: $ 67.57万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6821558
• 关键词: behavioral /social science research tag; case history; child behavior disorders; child mental disorders; clinical research; depression; disease /disorder onset; disease /disorder proneness /risk; electroencephalography; human subject; longitudinal human study; mood disorders; parent offspring interaction; pathologic process; patient oriented research; preschool child (1-5); reinforcer

DESCRIPTION (provided by applicant): Little is known about the precursors and early manifestations of depression. Recent theoretical and empirical work on temperament and mood disorders in adults and children has converged in suggesting that temperamental low positive emotionality (PE) may be a precursor of subsequent depressive disorders. We seek to begin to test this hypothesis by assessing temperament in a large community sample of 3-year old children, examining the relationship between low PE and two better established risk factors for depression, and investigating the stability of PE over a two-year period. Seven hundred and twenty subjects will complete laboratory assessments of temperament, and 396 will be selected for further study, including laboratory assessments of EEG and parent-child interactions; a battery of interview and rating scale measures of temperament and psychopathology in the children and their parents; and a follow-up evaluation atage 5. The project has six specific aims: (1) examine the structure of PE, parse its core components, and distinguish it from the near-neighbor construct of behavioral inhibition (BI); (2) test hypothesized associations between low PE and two other markers of risk for depression: maternal history of mood disorders and asymmetries in EEG activity (decreased left frontal and right parietal activity); (3) investigate the specificity of the low PE-depression relationship by determining whether child low PE is related to non-mood disorders in parents and EEG asymmetries that have been implicated in some forms of anxiety disorders (increased right frontal and right parietal activity) and exploring whether other temperament variables, such as BI, are also associated with a parental history of mood disorders and decreased left frontal and right parietal EEG activity; (4) evaluate the stability of low PE between the ages of 3 and 5, and examine its relationship to BI over time; (5) identify factors that might moderate the developmental trajectory of low PE (and ultimately the development of depression), such as other temperament variables, parental mood disorders, and parenting behavior; and (6) build the foundation for a long-term study that follows the sample into adolescence/young adulthood in order to determine whether low PE at age 3 predicts the subsequent onset of depression.

描述（由申请人提供）：人们对抑郁症的前兆和早期表现知之甚少。最近关于成人和儿童气质和情绪障碍的理论和实证研究一致表明，气质低积极情绪（PE）可能是随后抑郁症的先兆。我们试图通过评估大型社区 3 岁儿童样本的气质、检查低 PE 与两个更明确的抑郁症危险因素之间的关系，并调查 PE 在两年内的稳定性来开始检验这一假设。 。 720名受试者将完成气质实验室评估，并选择396名受试者进行进一步研究，包括脑电图和亲子互动的实验室评估；对儿童及其父母的气质和精神病理学进行一系列访谈和评级量表测量；以及5岁时的后续评估。该项目有六个具体目标：（1）检查PE的结构，解析其核心组成部分，并将其与行为抑制（BI）的近邻结构区分开； (2) 测试低 PE 与其他两个抑郁症风险标志之间的假设关联：母亲情绪障碍史和脑电图活动不对称（左额叶和右顶叶活动减少）； (3) 通过确定儿童低 PE 是否与父母的非情绪障碍以及与某些形式的焦虑症有关的脑电图不对称（右额叶和右顶叶活动增加）有关，研究低 PE 与抑郁关系的特异性探索其他气质变量（例如BI）是否也与父母的情绪障碍史以及左额叶和右顶叶脑电图活动减少有关； (4) 评估3岁至5岁之间低PE的稳定性，并检查其与BI随时间的关系； (5) 确定可能调节低 PE 发展轨迹（并最终发展为抑郁症）的因素，例如其他气质变量、父母情绪障碍和养育行为； (6) 为长期研究奠定基础，跟踪样本进入青春期/青年期，以确定 3 岁时的低 PE 是否可以预测随后的抑郁症发作。