Body size, physical activity, and Hodgkin's disease risk

体型、体力活动和霍奇金病风险

• 批准号: 6838960
• 负责人: SALLY L GLASER
• 金额: $ 6.97万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838960
• 关键词: Hodgkin' s disease; adult human (21+); body composition; body height; body physical activity; body physical characteristic; body weight; cancer risk; clinical research; comorbidity; disease /disorder proneness /risk; female; immune response; immunocytochemistry; in situ hybridization; questionnaires; socioeconomics

DESCRIPTION (provided by applicant): Hodgkin's disease (HD) is a common cancer of young adults for which etiology is far from established, and few novel leads have been identified. Scattered reports have linked HD risk with taller height, heavier weight and less physical activity. Body size and physical activity are believed to affect immune function and hormone regulation, both postulated as relevant to HD etiology, but their impact on HD risk has had very little consideration, especially in women. We propose to examine risk for HD in women associated with body size and physical activity over the life-span to test the hypotheses that: 1) Height in adulthood and relative height in childhood are associated with increased HD risk. 2) Birth weight and weight adjusted for height (body mass index) throughout adulthood are associated with HD risk. 3) Frequency of strenuous physical activity in adolescence and through adulthood is associated with HD risk. We will address these topics in data from detailed in-person interviews collected for a completed population-based case-control study of HD in women that had a high response rate, histologically re-reviewed diagnoses, and nearly complete data on 312 cases and 325 random-digit dialing controls frequency-matched to cases on age and race. With logistic regression, we will compute odds ratios to estimate risk associated with: adult height; relative height at ages 8 and 12; birth weight; weight adjusted for height through adulthood; and frequency of leisure-time strenuous physical activity through adolescence and adulthood and physical activity estimated for the longest-held occupation. All analyses will be adjusted for childhood social class, comorbidities, life-time smoking, and other confounders. We will have very good statistical power to detect odds ratios >=2.0, given likely risk factor prevalences. Interactions will be addressed through stratification of analyses by age group, race, histologic type, and EBV in tumor cells, as numbers permit; interactions between variables measuring childhood exposure and body size and physical activity will be considered in regression models. Study strengths include: 1) examination of under-studied risk factors novel for women; 2) a population basis; 3) strong data quality; 4) good to excellent statistical power; 5) re-reviewed diagnoses; 6) life-time body size and physical activity data; 7) detailed data on confounders. Study weaknesses include: 1) self-reported data; 2) limitation to strenuous leisure-time physical activity; 3) poor statistical power to examine associations in some subgroups; 4) potential recall bias and modest selection bias in controls.

描述（由申请人提供）： 霍奇金氏病（HD）是一种常见的年轻人癌症，病因远非建立，很少有新的铅。分散的报告将高清风险与高度，体重更高和体育锻炼更少联系起来。人们认为身体大小和体育锻炼会影响免疫功能和激素调节，均被认为与HD病因相关，但其对HD风险的影响很少，尤其是在女性中。我们建议检查妇女与寿命相关的体型和体育锻炼相关的女性HD风险，以测试以下假设：1）成年后的身高和儿童期相对身高与HD风险增加有关。 2）整个成年期针对身高调整的出生体重和体重与高清风险有关。 3）青春期和成年期的剧烈体育锻炼的频率与HD风险有关。我们将在数据中从具有较高应答率，组织学重新评估的诊断诊断的详细案例对照研究中收集的详细的面对面访谈中的这些主题，以及312例病例和325例随机拨号拨号控制频率与年龄和种族匹配的频率频率。通过逻辑回归，我们将计算赔率比率，以估计与以下相关的风险：成人身高； 8岁和12岁的相对身高；出生体重；重量调整为成年期的高度；在青春期和成年期间，休闲时间剧烈的体育锻炼的频率以及估计最长的职业的体育活动。所有分析将针对儿童社会阶层，合并症，终身吸烟和其他混杂因素进行调整。鉴于可能的风险因素流行，我们将具有非常好的统计能力来检测赔率> = 2.0。相互作用将通过数字允许的肿瘤细胞中按年龄组，种族，组织学类型和EBV分析来解决；在回归模型中，将考虑测量儿童暴露与身体大小和体育锻炼的变量之间的相互作用。研究优势包括：1）对女性新颖的研究危险因素的检查； 2）人口基础； 3）强大的数据质量； 4）良好至优异的统计能力； 5）重新审查的诊断； 6）终身身体大小和体育锻炼数据； 7）关于混杂因素的详细数据。研究弱点包括：1）自我报告的数据； 2）限制艰苦的休闲时间体育锻炼； 3）检查某些亚组中关联的统计能力差； 4）对照组中潜在的回忆偏差和适度的选择偏差。