Environmental Enrichment and Stereotyped Behavior

环境丰富和刻板行为

• 批准号: 6622456
• 负责人: CORTNEY A TURNER
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-05-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6622456
• 关键词: Peromyscus; behavior test; behavioral /social science research tag; biomarker; cell component structure /function; chordate locomotion; cytochrome oxidase; dendrites; developmental genetics; developmental neurobiology; developmental psychology; enzyme induction /repression; gene environment interaction; gene expression; histochemistry /cytochemistry; in situ hybridization; instinct; neural plasticity; neuroanatomy; neurochemistry; neurogenetics; neurons; neuropsychology; neuroregulation; neurotrophic factors; predoctoral investigator

The current research proposal utilizes an animal model of spontaneous and persistent stereotype to study the neurobiological basis of abnormal repetitive behavior in humans. The spontaneous stereotyped behaviors emitted by deer mice are responsive to the environmental conditions associated with rearing. Recently, we have demonstrated that environmental enrichment functions to reduce the development and expression of stereotypic behavior in deer mice, yet the mechanisms underlying this outcome remain unknown. This proposal will attempt to identify the structural and functional brain changes responsible for this effect. First, alterations in neuronal metabolic activity will be assessed in order to identify those brain regions where altered neuronal activity is associated with reduced vulnerability to develop stereotype. Secondly, differences in dendritic spine density and branching patterns will be assessed as a potential mechanism for the effects of environmental enrichment on neuronal activity and dendritic alterations. Thus, the proposed studies will attempt to identify CNS changes associated with the environmental enrichment-related decrease in the development of stereotype behaviors in deer mice.

目前的研究计划利用自发和持续刻板印象的动物模型来研究人类异常重复行为的神经生物学基础。鹿鼠自发的刻板行为是对与饲养相关的环境条件的反应。最近，我们证明环境丰富可以减少鹿小鼠刻板行为的发展和表达，但这一结果背后的机制仍然未知。该提案将尝试确定造成这种影响的大脑结构和功能变化。首先，将评估神经元代谢活动的改变，以确定神经元活动改变与降低形成刻板印象的脆弱性相关的大脑区域。其次，树突棘密度和分支模式的差异将被评估为环境富集对神经元活动和树突改变影响的潜在机制。因此，拟议的研究将尝试确定与环境富集相关的鹿小鼠刻板行为发展减少相关的中枢神经系统变化。