Supplemental Oxygen for Hypoxia-Related Retinal Deseases

补充氧气治疗缺氧相关的视网膜疾病

• 批准号: 6804702
• 负责人: QUAN DONG NGUYEN
• 金额: $ 17.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804702
• 关键词: angiogenesis; diabetic retinopathy; edema; eye fundus photography; fluorescein angiography; human subject; human therapy evaluation; hypoxia; image processing; longitudinal human study; macular degeneration; oxygen therapy; pathologic process; patient oriented research; retina disorder

DESCRIPTION: (Candidate's Abstract) Hypoxia is thought to play a role in the pathogenesis of several ocular diseases. It is Clear that hypoxia is the driving force behind the development of retinal neovascularization (NV) in patients with ischemic retinopathies, including diabetic retinopathy and central and branch retinal vein occlusions. Macular edema is another major cause of decreased vision in ischemic retinopathies and it is suspected, but not yet proven that hypoxia plays a critical role. Likewise, it is suspected, but not yet proven, that hypoxia contributes to the development of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD). Supplemental inspired oxygen provides a means to enhance oxygenation in the retina and choroid. We propose to use supplemental inspired oxygen to test several hypotheses related to the role of hypoxia in ocular NV and macular edema. The following experimental questions will be addressed. (1) Does supplemental inspired oxygen cause regression or slow progression of retinal NV that is not high risk in patients with diabetic retinopathy? (2) Does supplemental oxygen cause improvement in macular edema in patients with ischemic retinopathy? (3) Does supplemental oxygen cause stabilization or improvement in AMD patients with predominantly occult subfoveal CNV? (4) Does supplemental oxygen decrease recurrent CNV in AMD patients with predominantly classic CNV treated with photodynamic therapy? The answers to these questions will provide important insights into the pathogenesis of retinal diseases that could lead to the development of new treatments.

描述：（候选人摘要）缺氧被认为在多种眼部疾病的发病机制中发挥着重要作用。很明显，缺氧是 视网膜新生血管（NV）发展的驱动力 患有缺血性视网膜病的患者，包括糖尿病性视网膜病和 视网膜中央静脉和分支静脉阻塞。黄斑水肿是另一大病 缺血性视网膜病视力下降的原因，有人怀疑，但是 尚未证明缺氧起着关键作用。同样，有人怀疑， 但尚未证实，缺氧有助于脉络膜的发育 年龄相关性黄斑变性患者的新生血管形成（CNV） （AMD）。 补充吸入氧气提供了一种增强氧合的方法 视网膜和脉络膜。我们建议使用补充吸入氧气来测试 与缺氧在眼部 NV 和黄斑中的作用相关的几种假设 浮肿。将解决以下实验问题。 (1) 是否 补充吸入氧气可导致视网膜 NV 消退或缓慢进展 那是不是糖尿病视网膜病变患者的高危人群？ (2) 是否 补充氧气可改善黄斑水肿患者 缺血性视网膜病变？ (3) 补充氧气是否会导致病情稳定或 主要患有隐匿性黄斑中心凹下 CNV 的 AMD 患者是否有改善？ (4) 是否 补充氧气可减少 AMD 患者的复发性 CNV 光动力疗法治疗经典CNV？这些问题的答案 将为了解视网膜疾病的发病机制提供重要的见解 可能会导致新疗法的开发。