HIV/HCV: Neuropsychiatric and Neurophysiologic Features

HIV/HCV：神经精神学和神经生理学特征

• 批准号: 6842408
• 负责人: Elizabeth Louise Ryan
• 金额: $ 16.07万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-24 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6842408
• 关键词: AIDS /HIV neuropathy; HIV infections; basal ganglia; choline; clinical research; cognition disorders; comorbidity; hepatitis C; human subject; inositol; interview; magnetic resonance imaging; neocortex; neurophysiology; neuropsychological tests; patient oriented research; virus load; virus virus interaction

DESCRIPTION (provided by applicant): Career Development Plan: I am requesting five years of funding through a Mentored Patient-Oriented Research Career Development Award in AIDS Research (PA-03-086) in order to develop as an independent researcher investigating neuropsychiatric and neurophysiologic features of HIV/HCV coinfection. My overall goals are 1) to learn about HIV/HCV coinfection and its impact on the brain and 2) to implement a research project investigating cognitive, psychiatric, and neurophysiologic features of HIV/HCV coinfection. My ultimate career goal is to become an independent investigator of the neuropsychiatric features of comorbidities in neuroAIDS. Career Development Plan: A comprehensive program is proposed that includes a didactic curriculum, tutorials in magnetic resonance spectroscopy imaging (MRSI), neurobiology of HIV, HIV/HCV coinfection, and neuropsychiatric research methods. Background of Proposed Research Project: HIV/HCV coinfection is an emerging, significant comorbidity in neuroAIDS. To date, the neurobehavioral consequences of HIV/HCV coinfection have not been fully characterized although each virus has been shown to independently cause neuropsychiatric disturbance. Research Project Aims: To determine whether a differential effect of HCV viremia can be detected in brain via neurometabolites and in behavior via neuropsychologic deficits among HIV/HCV coinfected, HCV-only, and HIV-only monoinfected patients. Methods: One hundred HIV/HCV coinfected patients with and without HCV viremia as well as 50 HIV-only and 50 HCV-only patients will receive a MRSI, a psychiatric interview, and a neuropsychologic assessment. The study will test the hypothesis that HCV viremia is associated with increased choline, increased myo-inositol, and increased GIx as well as executive functioning deficits. Significance: This study will identify neuropsychiatric and neurophysiologic features of HCV viremia in HIV/HCV coinfection and will serve as a template for neuropsychiatric research of comorbidities in neuroAIDS.

描述（由申请人提供）： 职业发展计划：我请求通过艾滋病研究领域以患者为导向的研究职业发展奖 (PA-03-086) 提供五年的资金，以便发展成为一名研究神经精神病学和神经生理学的独立研究人员HIV/HCV 双重感染的特征。我的总体目标是 1) 了解 HIV/HCV 合并感染及其对大脑的影响，2) 实施一个研究项目，调查 HIV/HCV 合并感染的认知、精神和神经生理学特征。我的最终职业目标是成为神经艾滋病合并症的神经精神特征的独立研究者。职业发展计划：提出了一个综合计划，包括教学课程、磁共振波谱成像 (MRSI) 教程、HIV 神经生物学、HIV/HCV 合并感染和神经精神病学研究方法。拟议研究项目的背景：HIV/HCV 合并感染是神经艾滋病中一种新兴的、重要的合并症。迄今为止，尽管每种病毒已被证明可独立引起神经精神障碍，但 HIV/HCV 合并感染的神经行为后果尚未得到充分表征。研究项目目的：确定在 HIV/HCV 合并感染、仅 HCV 和仅 HIV 单一感染患者中，是否可以通过神经代谢物在大脑中检测到 HCV 病毒血症的差异效应，以及是否可以通过神经心理缺陷在行为中检测到 HCV 病毒血症的差异效应。方法：100 名患有或不患有 HCV 病毒血症的 HIV/HCV 双重感染患者以及 50 名仅感染 HIV 的患者和 50 名仅感染 HCV 的患者将接受 MRSI、精神病学访谈和神经心理学评估。该研究将检验丙型肝炎病毒血症与胆碱增加、肌醇增加、胃肠道增加以及执行功能缺陷相关的假设。意义：本研究将确定 HIV/HCV 合并感染中 HCV 病毒血症的神经精神学和神经生理学特征，并将作为神经艾滋病合并症的神经精神学研究模板。