Sensitization & Cross-Sensitization to Psychostimulants

敏化

• 批准号: 6626087
• 负责人: PAMELA B YANG
• 金额: $ 2.6万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6626087
• 关键词: amphetamines; attention deficit disorder; behavior test; behavioral /social science research tag; behavioral habituation /sensitization; central nervous system stimulants; chordate locomotion; disease /disorder model; dosage; evoked potentials; female; gene environment interaction; genetic strain; juvenile animal; laboratory rat; mature animal; mental disorder chemotherapy; methylphenidate; neuropharmacology; predoctoral investigator

DESCRIPTION: (Provided by Applicant): Repeated treatment with methylphenidate (MPD; Ritalin) and other psychomotor stimulants, such as amphetamine and cocaine, has been shown to cause behavioral sensitization in rats and humans. Behavioral sensitization is characterized by an increase in locomotor and/or stereotypic behavior. It is not known, however, whether the behavioral sensitization produced by MPD involves the same neuronal mechanisms as amphetamine and cocaine. More importantly, chronic administration of MPD may also result in cross-sensitization with other psychostimulants. Methylphenidate is widely used to treat attention deficit/hyperactivity disorder (ADHD). The objectives of this study are to determine whether early exposure to MPD in juvenile rats increases their sensitivity to the drug when they are adult rats and whether treatment with MPD in juvenile and adult rats produces cross-sensitization to amphetamine. The study will consist of (1) monitoring the locomotor activity of two strains of rats (a model of ADHD and its control) before and after acute and repeated MPD administration when the rats are young and as adults followed by an amphetamine treatment and (2) evaluating sensory evoked potentials before and after drug treatment in freely moving rats with electrodes implanted in brain regions believed to be involved with ADHD, behavioral sensitization, and cross-sensitization.

描述：（由申请人提供）： 重复使用哌醋甲酯（MPD；利他林）和其他精神运动药物治疗 兴奋剂，如安非他明和可卡因，已被证明会导致行为 大鼠和人类的致敏作用。行为敏感化的特点是 运动和/或刻板行为的增加。然而，不知道的是， MPD 产生的行为敏化是否涉及相同的神经元 机制如安非他明和可卡因。更重要的是，长期服用 MPD 还可能导致与其他精神兴奋剂的交叉过敏。 哌甲酯广泛用于治疗注意力缺陷/多动症 障碍（多动症）。本研究的目的是确定是否早期 幼年大鼠暴露于 MPD 会增加其对药物的敏感性 它们是成年大鼠，是否对幼年和成年大鼠进行 MPD 治疗 与安非他明产生交叉过敏。该研究将包括（1） 监测两种大鼠品系的运动活动（ADHD 模型和 其控制）在急性和重复MPD给药之前和之后，当 大鼠在幼年和成年后接受安非他明治疗，并且 (2) 自由评估药物治疗前后的感觉诱发电位 移动被植入据信相关大脑区域的电极的老鼠 患有多动症、行为过敏和交叉过敏。