Studies of the Flora and Predator Bacteria of Jordan

约旦植物区系和捕食者细菌的研究

基本信息

批准号：
6805230
负责人：
NICHOLAS H. OBERLIES
金额：
$ 23.23万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2006-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6805230
关键词：
Middle East antibiotics antineoplastics bacteria biological products centrally acting drug drug discovery /isolation drug screening /evaluation ecology folk medicine geographic difference international cooperation medicinal plants plant ecology plant extracts training

项目摘要

DESCRIPTION (provided by applicant): This R21 planning application proposes the development of an International Cooperative Biodiversity Group (ICBG) to investigate the biodiversity of the Hashemite Kingdom of Jordan (Jordan) for bioactive lead compounds useful for the treatment of human diseases and/or as viable agrochemicals (fungicides, larvacides, pesticides, etc.). The proposed studies build upon the historical successes, strong formal collaborations, and long-standing personal relationships between researchers at the Research Triangle Institute of North Carolina (RTI), the Virginia Polytechnic Institute and State University (VT), and the Jordan University of Science and Technology of Irbid, Jordan (JUST). Biodiversity proposed for investigation encompasses Jordanian plants and traditional botanicals, and the innovative area of Predator bacteria. Compound discovery focuses on three primary pharmacological areas: antimicrobial activity, anticancer activity, and central nervous system (CNS) activity. The six specific program areas are: 1) Flora for Lead Discovery from under-investigated Jordanian plants from diverse and unique environments (Botany and Biodiversity), 2) Flora for Herbal Drug Analysis based on safety and efficacy of medicinal plants used traditionally by the People of Jordan (Botany and Ethnobotany), 3) Predator Bacteria from the diverse topographical regions of Jordan (Microbiology and Biodiversity), 4) Bioassays for Lead Discovery in anticancer, antimicrobial, and CNS pharmacology and prescreening for general toxicity in the brine shrimp test (Pharmacology, Microbiology, and Toxicology), 5) Natural Products Chemistry to isolate, purify, and characterize bioactive lead compounds based on bioactivitybased fractionation and development of analytical reference compounds and standardization protocols for the analysis of commonly used Jordanian herbal medicinals (Pharmacognosy), and 6) Education, Training, and Economic Development for technology transfer in the form of course instruction and workshops in Jordan, training of Jordanian researchers and students in advanced chemical and pharmacological techniques at RTI and VT, and by stimulating and encouraging economic development opportunities resulting from the collective scientific output of the research team. Intellectual property rights and consideration of the People of Jordan have been agreed to in principle and plans for formalization of these agreements are outlined herein.

描述（由申请人提供）：此R21规划申请提议开发国际合作生物多样性小组（ICBG），以调查约旦哈希米特王国（约旦）生物活性铅化合物的生物多样性，可用于治疗人类疾病和/或作为可行的农产品（杀菌剂，幼虫，农药等）。拟议的研究基于北卡罗来纳州研究人员研究人员（RTI），弗吉尼亚理工学院和州立大学（VT）的研究人员之间的历史成功，强大的正式合作以及长期的个人关系。和Irbid的技术，约旦（Just）。提议进行研究的生物多样性涵盖了约旦植物和传统植物，以及捕食者细菌的创新区域。复合发现侧重于三个主要的药理学领域：抗菌活性，抗癌活性和中枢神经系统（CNS）活性。六个特定的计划领域是：1）植物群，可从多样化和独特的环境（植物学和生物多样性）中发现的约旦植物不足的铅发现，2）基于人民传统上使用的药用植物的安全性和功效，用于草药药物分析的植物群。约旦（植物学和民族植物学），3）约旦多样化地形区域的捕食者细菌（微生物学和生物多样性），4）4）在抗癌，抗菌病和CNS药理学和CNS药理学和预先预先毒性毒性毒性毒性毒性中的生物测定物的生物测定物（ 5）基于基于基于生物活化的分馏和开发分析参考化合物和标准化方案的生物活性铅化合物的天然产物化学，以分析生物活性铅化合物，以分析常见使用的Jordanian草药（药物学），以及分析的标准化方案，以分离，纯化和表征生物活性铅化合物，以分离，纯化和表征生物活性铅化合物，以分离，纯化和表征生物活性铅化合物，以分离，纯化和表征生物活性铅化合物，从而分离出生物活性铅化合物， 6）以Jordan的教学和讲习班的形式进行技术转移的教育，培训和经济发展，在RTI和VT的高级化学和药理学技术的培训，以及通过刺激和鼓励经济发展机会的高级化学和药理学技术的培训。研究团队的集体科学输出。在本文中概述了知识产权和约旦人民的考虑，并在本文中概述了这些协议的正式化计划。