FASEB RESEARCH CONFERENCE: NUCLEAR STRUCTURE AND CANCER

FASEB 研究会议：核结构与癌症

• 批准号: 6737287
• 负责人: Ronald Berezney
• 金额: $ 0.5万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-16 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737287
• 关键词: DNA replication; cell component structure /function; cell nucleus; gene expression; genetic regulation; meeting /conference /symposium; neoplastic cell; neoplastic process

DESCRIPTION (provided by applicant): This application is for partial funding for the 2003 FASEB Summer Research Conference on "Nuclear Structure and Cancer" to be held June 7-12, 2003 at the Vermont Academy in Saxtons River, Vermont. The conference is under the auspices of the Federation of American Societies for Experimental Biology (FASEB). There will be nine regular platform sessions, two workshops and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. There will also be a special "late breaking development" session in which participants will be selected to give short talks. This conference will provide a forum to evaluate the fundamental regulatory and clinical implications of modified organization of nucleic acids and regulatory proteins that control gene replication and expression in nuclei of tumors cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization of regulatory factors is gaining increased attention. With this in mind there is a need for a conference that is dedicated to examining the structural and functional properties of the interphase cell nucleus in cells that are compromised with the onset and progression of cancer. This is the only major meeting in the world that focuses on this specific topic. Correlations between nuclear morphology and gene replication and expression will be systematically explored. There will be a concerted effort to critically evaluate findings that interface between nuclear organization, genomic function and regulation. Consideration will be given to contributions from cellular, biochemical, genetic and molecular approaches and their integration into multidisciplinary approaches for understanding the connections among genomic organization, function and cancer. In so doing this meeting will address experimental strategies and high resolution state-of-the-art methodologies for defining in cancer cells alterations in nuclear architecture related to changes in gene replication, expression and regulation.

描述（由申请人提供）：此申请是为2003年6月7日至12日在佛蒙特州萨克斯顿河的佛蒙特州学院举行的2003年FASEB夏季研究会议的部分资金。 该会议是在美国实验生物学联合会（FASEB）的主持下。 将有9个常规平台会议，两个研讨会和两个海报会议。 将鼓励年轻的调查人员通过提交摘要的选择在常规平台和研讨会会议上进行简短的会谈。 还将举行一个特别的“晚期破裂发展”会议，其中将选择参与者进行简短的谈判。 该会议将提供一个论坛，以评估核酸修饰组织和调节蛋白的基本调节和临床意义，这些组织控制肿瘤细胞核中基因复制和表达的调节蛋白。 核形态与肿瘤相关的变化的研究和调节因素的亚核组织正在增加注意力。 考虑到这一点，需要进行一次会议，该会议致力于研究随着癌症的发作和进展而妥协的细胞中相间细胞核的结构和功能特性。 这是世界上唯一关注此特定主题的主要会议。 核形态与基因复制与表达之间的相关性将被系统地探索。 将有一致的努力批判性地评估核组织，基因组功能和调节之间接口的发现。 将考虑细胞，生化，遗传和分子方法的贡献及其整合到多学科方法中，以理解基因组组织，功能和癌症之间的联系。 在这次会议上，将解决与基因复制，表达和调节变化有关的癌细胞改变癌细胞改变癌细胞改变的最先进方法。