SLEEP/AROUSAL IN ADOLESCENCE: PATHWAYS TO ALCOHOL ABUSE

青春期的睡眠/觉醒：酗酒的途径

• 批准号: 6744114
• 负责人: Ronald E. Dahl
• 金额: $ 26.13万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6744114
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; anxiety disorders; arousal; behavior prediction; behavioral /social science research tag; case history; child psychology; circadian rhythms; clinical research; comorbidity; cortisol; disease /disorder onset; electroencephalography; family genetics; gender difference; hormone regulation /control mechanism; human puberty; human subject; longitudinal human study; mood disorders; neuropsychology; sleep

The program of research described in this application uses measures of sleep, arousal, pubertal timing, and family history of alcohol dependence to examine developmental trajectories from childhood affective disorders to adolescent alcohol problems. It is hypothesized that an altered pattern of sleep/arousal regulation in children with anxiety and affective disorders will predict elevated rates of alcohol abuse/dependence during clinical follow-up across late-adolescence and into early adulthood. This work builds upon an existing psychobiologic study where a broad range of biological, clinical, and family history data have been obtained in samples of children with depression, anxiety disorders, controls with high family loading for affective disorders, and low-risk controls. The investigations described in the current proposal will add a new set of measures and analyses to that existing study, in order to address key questions relevant to adolescent development, sleep and arousal regulation, and pathways to alcohol abuse/dependence into early adulthood. These new measures will include multi variate EEG analyses applied to previously collected sleep data. Subjects (n=367) had psychobiologic measures obtained at ages 8-14 years of age and will be followed longitudinally for alcohol use problems developing across adolescence. The study will also examine gender differences and the influence of early pubertal timing on the development of affective and alcohol disorders. The study will obtain new biologic data on an informative sub-sample of subjects (n=90) studied in later pubertal maturation (ages 14-21). The long-term goal of this research is to understand maturational changes in sleep, arousal, and affect regulation across adolescence relevant to the development of alcohol abuse and dependence. Advancing knowledge in these areas may lead to more effective early intervention strategies (prevention or early treatment) for alcohol abuse/dependence in targeted high-risk populations of youth.

此应用中描述的研究计划采用了 睡眠，唤醒，青春期的时机和酒精依赖的家族史检查 从童年情感障碍到青少年的发展轨迹 酒精问题。 假设睡眠/唤醒的模式改变了 患有焦虑和情感障碍儿童的调节将预测 在整个临床随访期间，酒精滥用/依赖性率提高 青年后期到成年初。 这项工作建立在现有的 心理生物学研究，其中广泛的生物学，临床和家庭 已经在患有抑郁症儿童的样本中获得了历史数据， 焦虑症，家庭负载高于情感障碍的控制， 和低风险控制。 当前提案中描述的调查 将在现有研究中添加一套新的措施和分析 解决与青少年发展，睡眠和唤醒有关的关键问题 监管，以及成年初期酗酒/依赖的途径。 这些新措施将包括应用于 先前收集的睡眠数据。 受试者（n = 367）有心理生物学措施 在8-14岁的年龄中获得，并将纵向遵循 饮酒问题在整个青春期发展。 这项研究也将 检查性别差异以及青春期早期时机对 情感和酒精疾病的发展。 该研究将获得新的 有关受试者的信息子样本（n = 90）的生物学数据（稍后研究） 青春期成熟（14-21岁）。 这项研究的长期目标是 了解睡眠，唤醒和影响调节的成熟变化 整个青春期与酗酒的发展有关 依赖。 在这些领域提高知识可能会导致更有效 酒精的早期干预策略（预防或早期治疗） 对有针对性的高风险人群的虐待/依赖。