Plasticity in the dorsal cochlear nucleus

耳蜗背核的可塑性

• 批准号: 6640517
• 负责人: GULAMALI A EMADI
• 金额: $ 3.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2004-05-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640517
• 关键词: auditory feedback; auditory nuclei; auditory stimulus; brain stem; cats; decerebration; dorsal column; electrophysiology; electrostimulus; evoked potentials; inferior colliculus; neural information processing; neural plasticity; neural transmission; neurons; olivary body; postdoctoral investigator; single cell analysis; synapses

DESCRIPTION (provided by applicant): The proposed research will examine plasticity of responses in the dorsal cochlear nucleus (DCN), one of the first sites of integrative processing within the auditory system. The strengths of inputs from somatosensory brainstern nuclei into the DCN will be manipulated using variations of established protocols for inducing long-term synaptic changes in other brain regions, including but not limited to tetanic electrical stimulation of the input pathways. Input through the somatosensory pathways will be used to investigate whether plastic changes of sound-evoked responses can be induced in the DCN. Finally, the sites of plastic changes will be examined using pharmacological manipulations and stimulation at selected sites within the somatosensory-DCN pathway. This research will provide insight into the association between the somatosensory and auditory systems and into the overall function of the DCN. The work will contribute to the general understanding of the mechanisms and functional significance of plastic changes within the brain, which are relevant to normal development, to pathology (such as somatic tinnitus), and to recovery after damage.

描述（由申请人提供）：拟议的研究将检查背侧耳蜗核（DCN）中反应的可塑性，这是听觉系统中最早的综合处理位点之一。通过已建立的方案的变化来操纵从体感的脑核向DCN进行输入的强度，以诱导其他大脑区域的长期突触变化，包括但不限于输入途径的四烷基电刺激。通过体感途径的输入将用于研究DCN中是否可以诱导声音诱发反应的塑性变化。最后，将使用药理学操纵和刺激体感体验-DCN途径的选定位点进行检查。这项研究将洞悉体感和听觉系统之间的关联以及DCN的整体功能。这项工作将有助于对与正常发育，病理学有关的机理的一般理解和塑性变化的功能意义，例如病理学（例如细胞鸣），以及损害后恢复。