Phytoestrogens and breast cancer risk

植物雌激素和乳腺癌风险

• 批准号: 6693824
• 负责人: Susan E McCann
• 金额: $ 11.64万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6693824
• 关键词: alcoholic beverage consumption; breast neoplasms; cancer risk; clinical research; dietary supplements; disease /disorder etiology; estrogens; estrone; female; genetic polymorphism; genetic susceptibility; hormone related neoplasm /cancer; human subject; lactones; lignans; neoplasm /cancer epidemiology; nutrition related tag; phytoestrogens; postmenopause; seeds; smoking; steroid 17alpha monooxygenase; steroid hormone metabolism; tobacco abuse; women' s health

DESCRIPTION (provided by applicant): The proposed Career Development Award will help Dr. Susan McCami gain independence in a career focused on the nutritional epidemiology of chronic disease, integrating her background in nutritional sciences and epidemiology, and gaining new expertise in molecular epidemiology. Her immediate goals as outlined below include an investigation of tho relationship between food components with hormonal activities (phytoestrogens) and breast cancer risk using retrospective and experimental designs and to collaborate with ongoing research in the Department of Social and Preventive Medicine (SPM). SPM has a long history of research in diet and cancer and is ideally suited for this research. In addition, she will receive training and insight into the integration of laboratory methods into epidemiology and the inclusion of genetic susceptibility in epidemiologic studies, and further training in onclogy, molecular epidemiology, and endocrinology. Proposed here are two studies examining the role of dietary phytoestrogens in the etiology of pre- and postmenopausal breast cancer. The first utilizes data from a large case-control study for which data collection is currently ongoing (ending Spring 2001). Analyses will examine rite relationship between dietary intakes of lignans (major phytoestrogen source) on breast cancer risk. Data from the controls will be utilized to examine the relationship between dietary lignan intake and other dietary, non-dietary, and biomarkers of nutrition and chronic disease risk factors. Finally, we will examine genetic susceptibility as a modifying factor on these relationships by estimating risk stratified by polymorphisms of genes related to estrogen metabolism, CYP 17 and COMT. The second study involves collection of new data investigating the effect of dietary lignan supplementation on serum estrogen and phytoestrogen levels, and the impact of CYP17 and COMT polymorphisms on this relationship. Subjects in the study will consume flaxseed supplements for seven days and differences between baseline and postsupplementation serum estrogen and phytoestrogen levels assessed. These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer.

描述（由申请人提供）：拟议的职业发展奖 将帮助苏珊·麦卡米（Susan McCami）博士在专注于 慢性疾病的营养流行病学，将她的背景纳入 营养科学和流行病学，并获得分子的新专业知识 流行病学。 她的直接目标如下概述包括调查 食物成分与荷尔蒙活动之间的关系 （植物雌激素）和乳腺癌风险使用回顾性和实验性 设计并与社会部正在进行的研究合作 和预防医学（SPM）。 SPM在饮食方面的研究历史悠久 癌症，非常适合这项研究。 此外，她会收到 培训和洞察实验室方法集成到 流行病学和流行病学中的遗传敏感性 研究以及进一步培训术语，分子流行病学和 内分泌学。 这里提出的是两项研究，研究了饮食植物雌激素在 绝经前和绝经后乳腺癌的病因。 第一个使用 来自目前数据收集数据的大型病例对照研究的数据 正在进行（2001年春季）。 分析将检查仪式的关系 木脂蛋白（主要植物雌激素来源）对乳腺癌风险的饮食摄入量。 来自控件的数据将用于检查 饮食木质木质摄入量以及其他饮食，非饮食和生物标志物的 营养和慢性疾病危险因素。 最后，我们将检查遗传 通过估计风险，敏感性是对这些关系的修改因素 由与雌激素代谢有关的基因的多态性分层，CYP 17 和COMT。 第二项研究涉及收集研究的新数据 饮食木质木质补充对血清雌激素和植物雌激素的影响 CYP17和COMT多态性对这种关系的水平以及CYP17和COMT多态性的影响。 研究中的受试者将食用亚麻籽补充剂7天，并且 基线和支持后血清雌激素和 评估了植物雌激素水平。 这些调查，结合了回顾性 以及实验设计以及遗传分析，将有助于阐明 饮食植物雌激素摄入量在激素的病因中的作用 敏感癌症。