GENETICS OF CORONARY ARTERY DISEASE IN ALASKAN NATIVES

阿拉斯加原住民冠状动脉疾病的遗传学

• 批准号: 6796417
• 负责人: Barbara v Howard
• 金额: $ 65.29万
• 依托单位: MEDSTAR HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-21 至 2005-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6796417
• 关键词: Alaskan Native American; Chlamydiaceae; atherosclerosis; atherosclerotic plaque; bacteria infection mechanism; cardiovascular disorder epidemiology; carotid artery; clinical research; cooperative study; coronary disorder; cytomegalovirus; disease /disorder proneness /risk; electrocardiography; family genetics; gene mutation; genetic markers; genotype; human subject; hypertension; interview; linkage mapping; obesity; phenotype; ventricular hypertrophy; virus infection mechanism

This application is a working partnership between the Native-owned, non-profit corporation that manages the health care of the Native Alaskans of the Norton Sound and certain Strong Heart Study (SHS) investigators. The Norton Sound Health Corporation, a subcontractor to the Indian Health Service, provides medical care for the approximately 8,000 Native Alaskans living along the shores of the Bering Straits. The investigators bring many years of successful collaboration and individual experience in the epidemiology and genetics of minority health. There are many compelling reasons to study heart disease in the Native Alaskans. These Eskimos villages are remote and isolated. The traditional lifestyle is being eroded by mechanization and a westernized diet. There has been relatively little outside genetic influence and they are, like the American Indians of the lower 48 states, beginning to show a marked acceleration in the prevalence of atherosclerosis and coronary artery disease. The specific aims of this proposal are to carefully document CVD and CVD risk factors among 1200 Native Alaskans who are members of approximately 40 families. We will use standardized methodologies that will allow comparison with other populations. This will be a family- based, cross-sectionally study. Recognized and emerging risk factors, and prevalent CVD will be documented in each individual through a standardized interview, physical exam, laboratory measurements, carotid ultrasound, ECG and a review of centralized medical records. We will assay contemporary samples and serum specimens stored at the Anchorage CDC (from many participants) antedating this study (10-20 years ago) for specific markers of inflammation and serologic responses. Through a ten-centimorgan map, we will attempt to find specific genes that related to CVD. This will be the first project to identify and map genes that contribute to risk of CVD in this unique and understudied population.

该应用程序是管理诺顿湾阿拉斯加原住民医疗保健的原住民拥有的非营利性公司与某些强心脏研究 (SHS) 调查人员之间的合作伙伴关系。诺顿桑德健康公司 (Norton Sound Health Corporation) 是印第安健康服务局 (Indian Health Service) 的分包商，为居住在白令海峡沿岸的约 8,000 名阿拉斯加原住民提供医疗服务。研究人员在少数民族健康的流行病学和遗传学方面带来了多年的成功合作和个人经验。研究阿拉斯加原住民的心脏病有许多令人信服的理由。这些爱斯基摩人的村庄地处偏远、与世隔绝。传统的生活方式正在被机械化和西化饮食所侵蚀。外界遗传影响相对较小，而且他们就像美洲 48 个州的印第安人一样，动脉粥样硬化和冠状动脉疾病的患病率开始显着加快。该提案的具体目标是仔细记录大约 40 个家庭的 1200 名阿拉斯加原住民的 CVD 和 CVD 风险因素。我们将使用标准化方法，以便与其他人群进行比较。这将是一项以家庭为基础的横断面研究。将通过标准化访谈、体检、实验室测量、颈动脉超声、心电图和集中医疗记录审查来记录每个人已识别的和新出现的风险因素以及流行的 CVD。我们将分析本研究之前（10-20 年前）储存在安克雷奇疾病预防控制中心（来自许多参与者）的当代样本和血清标本，以了解炎症和血清学反应的特定标志物。通过十厘摩图谱，我们将尝试寻找与CVD相关的特定基因。这将是第一个在这个独特且研究不足的人群中识别和绘制导致 CVD 风险的基因的项目。

项目成果

Fatty acids linked to cardiovascular mortality are associated with risk factors.

• DOI: 10.3402/ijch.v74.28055
• 发表时间: 2015
• 期刊: International journal of circumpolar health
• 影响因子: 1.3
• 作者: Ebbesson SO;Voruganti VS;Higgins PB;Fabsitz RR;Ebbesson LO;Laston S;Harris WS;Kennish J;Umans BD;Wang H;Devereux RB;Okin PM;Weissman NJ;MacCluer JW;Umans JG;Howard BV
• 通讯作者: Howard BV