Antitumor and Antiviral Nucleoside Analogues

抗肿瘤和抗病毒核苷类似物

• 批准号: 6640080
• 负责人: JIRI ZEMLICKA
• 金额: $ 18.63万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640080
• 关键词: aminopurine; antineoplastics; antiviral agents; cyclopropanes; cytomegalovirus; drug design /synthesis /production; herpes simplex virus 1; human immunodeficiency virus; neoplasm /cancer; nucleoside analog; prodrugs; stereoisomer; thiophosphate

DESCRIPTION (provided by applicant): New nucleoside and nucleotide analogues will be prepared and studied as antiviral antitumor agents.These compounds will include (i) gem-bis-(hydroxymethyl)methylenecyclopropanes, (ii) cyclicphosphates of gem-bis-(hydroxymethyl) methylenecyclopropanes, (iii) lipophilic phosphoralaninate prodrugs of gem-bis-(hydroxymethyl)methylenecyclopropanes, (iv) 7-(2-amino)purine analogues, (v) phosphonateanalogues of methylenecyclopropanes and (vi) resolution of R and S diastereoisomers of phosphoralaninate methylenecyclopropane prodrugs,synthesis of the respective phosphorothioates and study of stereochemistry of intracellular activation.

描述（由申请人提供）：将准备新的核苷和核苷酸类似物作为抗病毒抗肿瘤剂。这些化合物将包括（i）Gem-bis-（羟基甲基）甲基丙型丙烷丙烷，（II）Gem-bis--磷酸盐（II）甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基（II） Gem-bis-（羟基甲基）甲状腺丙烷的磷酸前药，（iv）7-（2-氨基）类似物，（V）（v）甲基环丙烷的磷酸磷酸化和（vi）磷酸化和（vi）的磷酸化和（vi）的磷酸化磷酸化磷酸化合物的（VI），相应的磷酸盐剂和细胞内激活的立体化学研究。