MENOPAUSAL TRANSITION: A BIOBEHAVIORAL MODEL OF SYMPTOMS

更年期过渡：症状的生物行为模型

• 批准号: 6438090
• 负责人: ELLEN S MITCHELL
• 金额: $ 40.01万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6438090
• 关键词: aging; behavioral /social science research tag; clinical research; depression; estradiol; estrone; female; genetic markers; genetic polymorphism; genetic regulation; hormone regulation /control mechanism; hormone therapy; human middle age (35-64); human subject; longitudinal human study; menopause; menstrual cycle; physiologic stressor; psychobiology; psychological stressor; questionnaires; sign /symptom; sympathetic nervous system; urinalysis; women's health

More than 20 million U.S. women of the Baby Boomer cohort will make th transition to menopause between 2000 and 2010. Despite women's increasing search for information about menopause, little is known about the natural history of the menopausal transition, those years before menopause. Our recent description of an early, middle and late stage of the menopausal transition allows us to continue this 10-year longitudinal study of a group of midlife women with a focus on hormone changes, perceived stress, physiologic stress arousal, symptoms, and depressed mood during three stages of the menopausal transition. An additional focus will be to assess the effects of genetic polymorphisms of the estrogen receptor gene (ESR1 PvuII) and estrogen metabolic genes (CYP17, CYP19, EDH17B2, CYP1A1, CYP1b1 enzymes) on estradiol and estrone levels, age of onset of middle and late transition and menopause, and menstrual bleeding. It is estimated that by the end of this proposed 5-year study the majority of women would have reached late transition or be menopausal. Data collection will involve obtaining a single blood sample for estradiol, a single buccal cell scraping for DNA analysis, four urine samples a year assayed for estrone, FSH, testosterone, cortisol and catecholamines, four 3-day symptom diaries per year, questionnaires, and yearly menstrual calendar. T he results of this study will help inform women and clinicians about normal changes associated with three stages of the menopausal transition and about genetic factors influencing estrogen levels, age of onset of stages of the menopausal transition and menopause and menstrual bleeding.

2000 年至 2010 年间，超过 2000 万美国婴儿潮一代女性将过渡到更年期。尽管女性越来越多地搜索有关更年期的信息，但人们对绝经前几年的更年期过渡的自然历史知之甚少。我们最近对更年期过渡早期、中期和晚期的描述使我们能够继续对一组中年女性进行为期 10 年的纵向研究，重点关注激素变化、感知压力、生理压力唤醒、症状和抑郁情绪在更年期过渡的三个阶段。另外一个重点将是评估雌激素受体基因（ESR1 PvuII）和雌激素代谢基因（CYP17、CYP19、EDH17B2、CYP1A1、CYP1b1酶）的遗传多态性对雌二醇和雌酮水平、中晚期发病年龄的影响。过渡期和更年期以及月经出血。据估计，到这项拟议的五年研究结束时，大多数女性将达到晚期过渡或更年期。数据收集将包括获取一份雌二醇血样、一份用于 DNA 分析的口腔细胞刮片、每年检测四份尿液样本的雌酮、FSH、睾酮、皮质醇和儿茶酚胺、每年四份为期 3 天的症状日记、调查问卷以及每年的月经日历。这项研究的结果将帮助女性和临床医生了解与更年期过渡的三个阶段相关的正常变化，以及影响雌激素水平、更年期过渡阶段的发病年龄以及绝经和月经出血的遗传因素。