Multicenter Network of Neonatal Intensive Care Units

新生儿重症监护室多中心网络

• 批准号: 6520809
• 负责人: JON E. TYSON
• 金额: $ 29.29万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6520809
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

The PI is Jon Tyson, MD, MPH, is the Michelle Bain Distinguished Professor of Medicine and Public Health, Director of the Center for Population Health and Evidence-Based Medicine, and a Professor of Pediatrics, Obstetrics, and Epidemiology at UT Houston. Th Co-PI is Kathleen Kennedy, MD who is an Associate Professor of Pediatrics and the Director of the Perinatal Epidemiology Program UT Houston was added to the Network in 1998 when the PI and Co-PI moved from UT Southwestern. UT Houston provides: A. A large and growing patient population. A total of 9,000 total births and 350 VLBW infants are projected this year for our 2 teaching hospitals: Memorial Hermann Hospital (a private hospital with an expanding referral base including 9 hospitals in the Memorial Hermann system [3 staffed by our Ob. Faculty]) and Lyndon Baines Johnson Hospital (a large county hospital with an increasing population). UT Houston's enrollment in the Glutamine Trial exceeds that for all but 2 of the other 13 Network centers. B. Strong, and highly supportive leadership at UT Houston. The Dean (Max Buja, MD) recruited Dr. Tyson to promote clinical research. The Ob. Chairman (Larry Gilstrap) is a perinatal investigator and Network consultant. The Pediatrics Chairman (John Sparks, MD) is a neonatologist and Network advocate. The Neonatology Director (Fernando Moya, MD) is Hermann Physician of the Year and skilled in conducting clinical research, eliciting hospital support, and augmenting enthusiasm for Network studies. C. An experienced and highly committed PI and Co-PI. Dr Tyson has been a PI for 13 years; Dr. Kennedy, Co-PI for 9 years and acting PI for 1 year. In the past 4 years, they have been an author on 16 Network publications, 3 as 1st author; 3 as 2nd author, and 1 as 3rd author. (4 of these were published in New England Journal or JAMA.) In moving to Houston, Dr. Tyson petitioned NICHD to include both UT Southwestern and UT Houston (rather than UT Houston only) in the Network and has served as PI for both. He has helped the Co-PI at UT Southwestern to apply as PI there for the next funding cycle. Dr. Tyson has involved multiple other faculty and fellows in the Network including Robert Lasky, PhD a developmental psychologist with expertise in neural processing; Terri Major-Kincade, MD,MPH, 1st recipient of the Network Specialized Clinical Investigator Development Award; and Martin Blakely, MD a pediatric surgeon whose K23 proposal (Dr. Tyson as mentor) is focused on Network studies. D. Methodological and multidisciplinary expertise. The Network can further advance the methods of clinical research and enrich the evaluation of important neonatal issues. Dr. Tyson is an epidemiologist and neonatologist, the PI for the NIH-funded Clinical Research Curriculum, and Director of the Master's Degree Program in Clinical Research to start here. The Center for Population Health and Evidence- Based Medicine that he directs includes 9 faculty with expertise in clinical or population-based epidemiology, biostatistics, developmental psychology, health care economics, and/or bioethics; 3 of these faculty are now involved in Network studies. John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001.

PI是医学博士Jon Tyson，MPH，是米歇尔·贝恩（Michelle Bain）杰出的医学和公共卫生教授，人口健康和循证医学中心主任，以及乌特休斯顿的儿科，妇产科和流行病学教授。 Co-Pi是医学博士凯瑟琳·肯尼迪（Kathleen Kennedy），他是儿科副教授，围产期流行病学计划UT休斯顿的主任于1998年将PI和Co-Pi从UT西南迁移时，将其添加到该网络中。 UT休斯顿提供：A。大量且不断增长的患者人群。预计今年为我们的两家教学医院预计，总共有9,000份分娩和350名VLBW婴儿：纪念赫尔曼医院（一家私人医院，具有扩大转诊基地的私人医院，其中包括纪念赫尔曼系统中的9家医院[3家由我们的ob。教职员工组成]和Lyndon Baines Johnes Johnes Hospital（一家大型县医院）。 UT休斯顿参加谷氨酰胺试验的入学量超过了其他13个网络中心中的2个。 B. Strong，在UT休斯顿提供了高度支持的领导。院长（马里兰州马克斯·布贾（Max Buja））招募了泰森（Tyson）博士来促进临床研究。 OB。董事长（Larry Gilstrap）是围产期调查员兼网络顾问。儿科主席（医学博士John Sparks）是新生儿学家和网络倡导者。新生儿学总监（医学博士Fernando Moya）是Hermann年度医生，擅长进行临床研究，引起医院支持以及增强网络研究的热情。 C.经验丰富且高度投入的PI和Co-Pi。泰森博士一直是PI 13年。肯尼迪博士（Co-Pi）肯尼迪（Kennedy）9年，并在PI上表演了1年。在过去的四年中，他们一直是16个网络出版物的作者，第3名是第一作者。 3作为第二作者，第三作者为第三作者。 （其中有4个发表在《新英格兰杂志》或《贾马》中。）泰森博士在搬到休斯顿，请NICHD申请NICHD，将UT西南和UT休斯顿（而不是仅限UT休斯顿）纳入了网络，并已作为两者的PI。他帮助西南UT的Co-Pi在下一个资金周期中申请了PI。泰森博士在网络中涉及其他多个教职员工和研究员，包括罗伯特·拉斯基（Robert Lasky），博士学位的发展心理学家，具有神经处理方面的专业知识； Terri Major-Kincade，医学博士，MPH，网络专业临床研究者开发奖的第一名；马丁·布拉克利（Martin Blakely），医学博士，一名儿科医生，其K23提案（泰森（Tyson）作为导师）专注于网络研究。 D.方法论和多学科专业知识。该网络可以进一步推进临床研究的方法，并丰富对重要新生儿问题的评估。 Tyson博士是一名流行病学家和新生儿学家，是NIH资助的临床研究课程的PI，也是临床研究硕士学位课程的主任。他指导的人口健康和循证医学中心包括9位具有临床或人群流行病学，生物统计学，发育心理学，卫生保健经济学和/或生物伦理学专业知识的教师；这些教师中有3个现在参与了网络研究。约翰·C·辛克莱（John C.