RELATION OF FAMILY HISTORY TO CARDIOVASCULAR REACTIVITY TO STRESS IN HISPANICS

西班牙裔人群的家族史与心血管压力反应的关系

• 批准号: 6598186
• 负责人: JOSEPH W TOMAKA
• 金额: $ 11万
• 依托单位: UNIVERSITY OF TEXAS EL PASO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6598186
• 关键词: Hispanic Americans; appetite; behavioral /social science research tag; blood pressure; cardiovascular disorder; cardiovascular function; clinical research; coping; emotional adjustment; emotions; family genetics; functional ability; human subject; parent offspring interaction; prejudice; psychophysiology; stress; stressor; vasomotion

DESCRIPTION (Applicant's Abstract): We propose a series of experiments exploring the relations between family history of cardiovascular disorder (FH) and stress-related cardiovascular reactivity among Hispanics. Besides our pilot research, there are essentially no studies examining FH's relation to cardiovascular reactivity among Hispanics. The proposed research extends a previously funded NIMH Grant [MH 47167-05S1] awarded to the PI. Most relevant is preliminary data examining FH's relation to stress responses among Hispanics. Briefly, young, normotensive Hispanics with a positive FH (FH+) had greater resting blood pressure (BP), and greater BP reactivity to stress, than Hispanics with a negative family history (FH). Different hemodynamic patterns, and different cognitive and affective reactions, accompanied the BP responses of FH+ and FH- participants. FH+ persons evidenced high cardiac activation coupled with low vascular resistance, whereas FH- persons evidenced low cardiac activation coupled with high vascular resistance. FH+ persons cognitively appraised the stress task as a challenge, and had more positive emotional reactions, than FH- participants. The cognitive, cardiovascular, and affective data suggest that FH+ participants were challenged by the stressor, whereas FH-participants felt threatened. These data suggest that FH- cardiovascular reactivity associations may not contribute to hypertension among Hispanics. We propose five studies that address limitations of the pilot study. Study 1 addresses sample size limitations, gender, and the stressor relevance among FH+ and FH- individuals. Study 2 examines FH's relation to stress reactions in appetitive and aversive situations. Study 3 examines FH's association with stress reactions during prolonged stress and during recovery from prolonged stress. Study 4 examines FH's association to stress reactions during ethnically harassing and non-harassing situations. Study 5 examines the correspondence of stress reactions between parents and their young normotensive offspring. In addition to examining FH's contribution to stress-related responding among Hispanics, all studies will examine how Hispanics respond and cope with stress in general.

描述（申请人的摘要）：我们提出了一系列实验 探索心血管疾病（FH）家族史之间的关系 以及西班牙裔人与压力相关的心血管反应。除了我们的飞行员 研究中，基本上没有研究检验 FH 与 西班牙裔人的心血管反应性。拟议的研究扩展了 先前资助的 NIMH 拨款 [MH 47167-05S1] 授予 PI。最相关的 是检验 FH 与应激反应关系的初步数据 西班牙裔。简而言之，血压正常且 FH 呈阳性 (FH+) 的年轻西班牙裔人 与压力相比，静息血压 (BP) 更高，血压对压力的反应性更强 有阴性家族史 (FH) 的西班牙裔人。不同的血流动力学模式， 以及不同的认知和情感反应，伴随着血压反应 FH+ 和 FH- 参与者。 FH+ 人群表现出高心脏激活 加上低血管阻力，而 FH- 人则表现出低心脏功能 激活与高血管阻力相结合。 FH+ 认知能力强的人 将压力任务视为一种挑战，并且有更积极的情绪 反应，比 FH- 参与者。认知、心血管和情感 数据表明，FH+ 参与者受到压力源的挑战，而 FH-参与者 感到受到威胁。这些数据表明 FH-心血管 反应性关联可能不会导致西班牙裔高血压。 我们提出了五项研究来解决试点研究的局限性。研究1 解决 FH+ 中的样本量限制、性别和压力源相关性 和FH-个人。研究 2 研究了 FH 与应激反应的关系 食欲和厌恶的情况。研究 3 检查 FH 与 长期应激期间以及从长期应激中恢复期间的应激反应 压力。研究 4 检查 FH 与种族期间压力反应的关联 骚扰和非骚扰情况。研究 5 检查了以下对应关系 父母和血压正常的年轻后代之间的压力反应。在 除了检查 FH 对压力相关反应的贡献外 西班牙裔，所有研究都将考察西班牙裔如何应对和应对压力 一般来说。