CARDIOVASCULAR PHENOTYPING IN MICE

小鼠心血管表型分析

• 批准号: 6617030
• 负责人: ROBERT M WEISS
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6617030
• 关键词: aging; bioimaging /biomedical imaging; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; disease /disorder onset; echocardiography; heart catheterization; laboratory mouse; method development; myocardium disorder; neoplasm /cancer blood supply; neoplasm /cancer diagnosis; phenotype; ultrasonography

DESCRIPTION (provided by applicant): This Award will provide support for the establishment and operation of a core facility for mouse cardiovascular phenotyping. It will also support three projects with implications for aging research: 1) adult-onset cardiomyopathy in mice; 2) age-induced placental insufficiency in mice; and 3) functional tumor vasculogenic mimicry. The application includes specific plans to mentor young investigators who select careers in translational cardiovascular research. Specific long-term career goals: 1) Operate an internationally recognized cardiovascular mouse phenotyping core facility; 2) advance the understanding of the cellular basis of heritable dilated cardiomyopathy, and develop diagnostic and therapeutic modalities with the potential for clinical application; 3) determine the nature and magnitude of impairment of maternal-placental circulation in murine disease states which recapitulate important clinical conditions, and develop therapeutic strategies which have potential for clinical application; 4) apply newfound knowledge about the function of tumor vasculogenic mimicry channels toward improved cancer diagnosis and treatment; and 5) develop and implement a training program in translational mouse cardiovascular research, dedicated toward fostering the careers of future independent investigators. These goals will be pursued by application of current methods and development of new methods for investigation of mouse cardiovascular function in vivo. The project will initially rely on ultrasonography and cardiac catheterization to achieve its Specific Aims. During the course of the Award, new methods for cardiovascular studies in mice will be tested and implemented. Ultimately, the information gained by these studies in mice will form the foundation for the development of novel and feasible advances in the diagnosis and treatment of patients with cardiovascular disorders.

描述（由申请人提供）： 该奖项将为小鼠心血管表型的核心设施的建立和运营提供支持。 它还将支持三个对衰老研究影响的项目：1）小鼠成人发作的心肌病； 2）年龄引起的小鼠胎盘不足； 3）功能性肿瘤血管生成模仿。 该应用程序包括指导年轻研究人员的特定计划，这些调查员在转化心血管研究中选择职业。 特定的长期职业目标：1）经营国际认可的心血管鼠标表型核心设施； 2）提高对遗传性扩张心肌病的细胞基础的理解，并发展出具有临床应用潜力的诊断和治疗方式； 3）确定在鼠类疾病状态下母体盆栽循环损伤的性质和大小，这些状态概括了重要的临床状况，并制定具有临床应用潜力的治疗策略； 4）将有关肿瘤血管生成模仿通道功能的新发现知识应用于改善癌症的诊断和治疗； 5）在翻译小鼠心血管研究中制定和实施培训计划，致力于培养未来独立研究者的职业。 这些目标将通过应用当前方法和开发新方法来调查体内小鼠心血管功能。 该项目最初将依靠超声检查和心脏导管插入术来实现其特定目标。 在奖项过程中，将测试和实施小鼠心血管研究的新方法。 最终，这些研究在小鼠中获得的信息将构成发展心血管疾病患者诊断和治疗的新颖和可行进步的基础。