Cooperation among subcortical networks underlying memory

记忆底层皮层下网络之间的合作

• 批准号: 6399661
• 负责人: BERNAT KOCSIS
• 金额: $ 27.56万
• 依托单位: MASSACHUSETTS MENTAL HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-06 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6399661
• 关键词: brain electrical activity; brain stem; diencephalon; hippocampus; laboratory rat; memory; psychomotor function; sleep; wakefulness

DESCRIPTION (provided by the applicant): The role of hippocampus in memory is well established and the importance of subcortical structures connected to the hippocampus has been known since the pioneering work of Korsakoff and Wernicke. Although certain memory deficits are best described in the frameworks of a diencephalo-hippocanipal syndrome, virtually nothing is known about how these forebrain systems interact with each other and how their interaction is organized by the brainstem so as to account for the robust state dependent changes underlying learning and memory. The central focus of this project is the subcortical regulation of hippocampal function and is guided by the general hypothesis that the role of this regulation is not only to switch the hippocampal EEG between theta and non-theta patterns but also to build dynamic associations between several limbic structures that are synchronized by the theta rhythm. Extrahippocampal theta activity has been recently described in a number of structures under urethane anesthesia but never under natural conditions. The proposed research will test the hypotheses that (1) brainstem/diencephalic systems, in addition to switching between theta and non-theta take part in behaviorally-related fine tuning of hippocampal activity during natural theta states; (2) theta rhythmic activity plays a role in neuronal cooperation between different limbic structures and brainstem structures exhibiting theta rhythmic activity specifically regulate this traffic; (3) theta rhythmic activity generated in the septum and the mammillaiy complex exerts feedback regulatory influence on brainstem nuclei involved in brain state regulation. Phasic and rhythmic synchronization of neuronal activity is critical to the concerted action of spatially separated structures in the brain. Theta synchrony provides an excellent model to study such cooperation and the way in which it differs in specific behavioral states. Our experiments will take advantage of waking exploration and sleep as a natural experiment trying to inform us about the components of the memory building process. The timeliness of this work is underlined by the recent upsurge of interest and data linking sleep, hippocampal activity and successive phases of information processing in non-REM and REM sleep.

描述（由申请人提供）：海马体在记忆中的作用是 皮层下结构的确立和重要性与 自从科萨科夫和韦尼克的开创性工作以来，海马体就为人所知。 尽管某些记忆缺陷可以在以下框架中得到最好的描述： 间脑-海马综合征，实际上我们对这些疾病是如何发生的一无所知 前脑系统彼此相互作用以及它们的相互作用是如何的 由脑干组织，以解释强大的状态依赖性 改变潜在的学习和记忆。 该项目的重点是海马的皮层下调节 函数并受一般假设的指导，即该函数的作用 调节不仅是在 θ 和 θ 之间切换海马脑电图 非 theta 模式，还可以在多个模式之间建立动态关联 由 theta 节律同步的边缘结构。海马外 最近在许多结构中描述了 theta 活动 聚氨酯麻醉，但绝不在自然条件下进行。拟议的研究 将测试以下假设：(1) 脑干/间脑系统，此外 在 theta 和 non-theta 之间切换 参与行为相关的罚款 在自然 theta 状态下调整海马活动； (2) θ节奏 活动在不同边缘系统之间的神经元合作中发挥作用 表现出θ节律活动的结构和脑干结构 特别监管该流量； (3) 产生的theta节律活动 隔膜和乳头复合体发挥反馈调节作用 脑干核参与大脑状态调节。 神经元活动的阶段性和节律性同步对于 大脑中空间分离的结构的协同作用。西塔 同步提供了一个很好的模型来研究这种合作及其方式 它在特定的行为状态下有所不同。我们的实验将采取 清醒探索和睡眠作为自然实验的优势 告诉我们记忆构建过程的组成部分。时效性 最近兴趣和数据链接的高涨强调了这项工作的重要性 睡眠、海马活动和信息处理的连续阶段 非快速眼动睡眠和快速眼动睡眠。