Hostility, Race, and Glucose Metabolism

敌意、种族和葡萄糖代谢

• 批准号: 6579765
• 负责人: RICHARD SAMUEL SURWIT
• 金额: $ 52.23万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6579765
• 关键词: African American; angers; behavioral /social science research tag; blood glucose; body composition; catecholamines; caucasian American; clinical research; cortisol; glucose metabolism; glucose tolerance; glucose tolerance test; health disparity; human subject; hypothalamic pituitary adrenal axis; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; psychometrics; racial /ethnic difference

DESCRIPTION (provided by applicant): Recent research in our laboratory has provided evidence that the metabolic correlates of hostility may play a role in the racial disparity in the prevalence of type 2 diabetes. We propose to study how hostility is differentially related to glucose metabolism in healthy African-Americans and Caucasians, to determine the underlying behavioral and physiologic mechanisms of these relationships, and to investigate the possibility that race and sex interact in determining this relationship. We will assess the multi-factorial nature of hostility in 400 healthy African-American and Caucasian men and women. These psychometric measures will be examined in relation to fasting and two-hour post-prandial glucose and insulin as well as hemoglobin AIC (HbAIC) on all subjects. We will test the hypothesis that hostility is related to insulin resistance in Caucasians and to glucose production and defective glucose-stimulated insulin secretion in African-Americans, putting hostile African-Americans at greater risk for developing diabetes. Accordingly, we will assess glucose-stimulated insulin release, insulin resistance, hepatic glucose production and glucose effectiveness utilizing an IV GTT with labeled glucose in a subset of our sample. We will begin to determine the mechanism by which hostility impacts glucose metabolism in an African-American and Caucasian population. Three sets of mediators will be examined in the subjects studied parameters of hypothalamic-pituitary-adrenal (HPA) axis activity, measures of body mass and fat distribution, and measures of behavioral factors including calorie intake and exercise habits. It is further hypothesized that while the relationship of hostility to fasting insulin and insulin sensitivity in Caucasians is mediated by BMI and behavioral variables, the relationship of hostility to fasting glucose in African-Americans will depend on neuroendocrine factors influencing hepatic glucose production and insulin secretion. These studies will further our understanding of the differences in the etiology of diabetes in these ethnic groups and may help explain the racial disparity in this disease.

描述（由申请人提供）：我们实验室的最新研究提供了证据表明，敌对行为的代谢相关性可能在2型糖尿病患病率的种族差异中起作用。我们建议研究健康非裔美国人和高加索人中敌对与葡萄糖代谢有差异的关系，以确定这些关系的潜在行为和生理机制，并研究种族和性别在确定这种关系中相互作用的可能性。我们将评估400名健康的非裔美国人和高加索男女的敌对性的多因素性质。这些心理测量指标将在所有受试者的禁食和两个小时的餐后葡萄糖和胰岛素以及血红蛋白AIC（HBAIC）方面进行检查。我们将检验以下假设：敌对性与高加索人的胰岛素抵抗有关，以及在非裔美国人中葡萄糖的产生和葡萄糖刺激的胰岛素分泌有缺陷，使敌对的非裔美国人面临更大的糖尿病风险。因此，我们将利用带有标记的葡萄糖在样本的子集中评估葡萄糖刺激的胰岛素释放，胰岛素抵抗，肝葡萄糖产生和葡萄糖有效性。我们将开始确定敌对行动影响非裔美国人和高加索人群中葡萄糖代谢的机制。在研究的受试者中，将检查三组介体的辅助参数（HPA）轴活动，体重和脂肪分布的度量以及包括卡路里摄入和运动习惯在内的行为因素的度量。进一步假设，尽管BMI和行为变量介导了敌对性与禁食胰岛素和胰岛素敏感性的关系，但敌对性与非裔美国人禁食葡萄糖的关系将取决于影响肝葡萄糖产生和胰岛素分泌的神经内分泌因子。这些研究将进一步理解这些种族糖尿病病因的差异，并可能有助于解释这种疾病的种族差异。