ACTIVITY REFINES CORTICOSPINAL TERMINATIONS

活动改善皮质脊髓终止

• 批准号: 6627669
• 负责人: John H Martin
• 金额: $ 30.03万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6627669
• 关键词: botulinum toxins; cats; cytochrome oxidase; developmental neurobiology; early experience; electromyography; immunocytochemistry; muscimol; neuronal transport; neuropharmacology; psychomotor function; pyramidal tracts; sensorimotor system; spinal cord; synaptic vesicles

DESCRIPTION: (adapted from applicant's abstract) This is a revised application for renewal of a research project aiming to determine how motor experience during early life influences the development of the cortical motor representations and corticospinal connections. The first aim is to study the relationships between the normal morphological and functional development of CS axon terminal arbors. The second aim is to determine the roles of motor experience and neural activity during early life in shaping the functional and morphological development of corticospinal terminal arbors and of cortical motor representations. The third aim is to determine the effects of impaired limb use or cortical activity blockade during development on kinematics and dynamic control of skilled movements. By understanding experiential factors influencing early development of the corticospinal system and skilled movements, the investigators hope to devise more targeted interventional and rehabilitation strategies.

描述：（改编自申请人的摘要） 这是续签研究项目的修订申请，旨在 确定早期生活中的运动经验如何影响 皮质运动表示和皮质脊髓连接。第一个目标 是研究正常形态和功能之间的关系 CS轴突末端乔木的开发。第二个目的是确定 运动经验和早期生命中神经活动的作用在塑造 皮质脊髓末端乔木和形态发展 皮质运动表示。第三个目的是确定 开发过程中的肢体使用或皮质活动阻碍受损 运动学和熟练运动的动态控制。通过理解 影响皮质脊髓系统早期发展的经验因素 和熟练的运动，调查人员希望设计更多针对性的 介入和康复策略。