Control System for MRI Monitored Thermal Therapies

MRI 监测热疗控制系统

• 批准号: 6641092
• 负责人: GARY P ZIENTARA
• 金额: $ 28.72万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-06 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6641092
• 关键词: computer assisted patient care; computer human interaction; computer program /software; computer system design /evaluation; computer system hardware; human data; human therapy evaluation; magnetic resonance imaging; neoplasm /cancer; neoplasm /cancer thermotherapy; quality of life

DESCRIPTION (Verbatim from Applicant's Abstract): We propose to develop, implement, and validate use of a computerized control system for MR-monitored thermal therapies (interstitial laser thermal therapy and cryotherapy) that is to be attached to our 0.5T open configuration interventional MR scanner. The system will utilize 3D MRI information, providing audible and visual prior warning signals and an alarm signal at the therapy endpoint. We aim to directly answer the cancer treatment clinical need for accurate 3D spatial-temporal monitoring and control of tumor thermal therapies in heterogeneous tissue, currently beyond human capability, to guarantee patient safety while optimizing therapy effectiveness. Our proposed system will provide recognizable prior warning signals before the endpoint is reached, and an alarm signal at the instance when the thermal therapy endpoint occurs, as the thermal exposure level or therapy boundary meets or exceeds pre-defined 3D boundaries or safety limits. Specifically, our project consists of: (1) the integration of specially configured computer hardware into our interventional MR scanner electronics; (2) the development of a software package and user-interface for 3D monitoring and control of a thermal ablation therapy based on a physician-specified therapy volume boundary and exposure limit; (3) initial off-line system testing using gel phantoms and posttreatment human patient MRI data; and, (4) fully on-line real-time validation testing during tumor thermal therapies on our interventional MR scanner. Software will be developed or integrated into the system to provide state-of-the-art capability for monitoring and predicting evolving therapy margins and thermal exposure. In Software Module One, a monitoring and control system will be developed based on 3D optical flow, previously demonstrated as clinically useful in our hospital. In Software Module Two, a parallel predictive pathway will be created combining existing fast 3D data segmentation and heat conduction modeling software. In Trial Phase One, off-line (not in real-time) gel and 'virtual' patient tests will be performed and control case data acquired. Later, in Trial Phase Two, real-time validation trials will take place during clinical therapy cases, to study the accuracy, usefulness and timeliness of the system results when executing on the specific computer hardware chosen for implementation.

描述（逐字研究来自申请人的摘要）：我们建议开发，实施和验证使用计算机控制系统以MR监测 热疗法（间质性激光疗法和冷冻疗法）就是 要附加到我们的0.5T开放配置介入MR扫描仪。这 系统将利用3D MRI信息，提供可听见和视觉事先 治疗端点处的警告信号和警报信号。我们的目标是直接 回答癌症治疗的准确3D时空的临床需求 监测和控制异质组织中肿瘤热疗法， 目前超出人类能力，以确保患者的安全，同时优化 治疗有效性。我们提出的系统将提供可识别的先验 到达端点之前的警告信号，并在 当热疗法终点发生时，随着热暴露 水平或治疗边界符合或超过预定的3D边界或安全性 极限。具体而言，我们的项目包括：（1）特别集成 将计算机硬件配置为我们介入的MR Scanner电子产品； （2）开发用于3D监视的软件包和用户界面 并控制基于医师指定的热消融疗法 治疗量边界和暴露限制； （3）初始离线系统测试 使用凝胶幻像和治疗后人类患者MRI数据；和，（4）完全 我们的在线实时验证测试在我们的肿瘤热疗法期间 介入的先生扫描仪。软件将被开发或集成到 提供监视和预测的最先进功能的系统 不断发展的治疗缘和热暴露。在软件模块一中 监视和控制系统将根据3D光流， 以前在我们的医院证明是临床上有用的。在软件中 第二个模块，将创建一个并行预测途径，以结合现有 快速3D数据分割和热传导建模软件。在试验阶段 一个，离线（不是实时）凝胶和“虚拟”患者测试将是 执行并控制案例数据。后来，在第二阶段，实时 验证试验将在临床治疗病例中进行，以研究 执行系统时系统的准确性，有用性和及时性 选择用于实施的特定计算机硬件。