PSYCHOPATHOLOGY AND COURSE OF RECURRENT ABDOMINAL PAIN

复发性腹痛的精神病理学和病程

• 批准号: 6528095
• 负责人: John Vincent Campo
• 金额: $ 15.88万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-20 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528095
• 关键词: abdomen; adolescence (12-20); anxiety; behavioral /social science research tag; clinical research; curriculum; functional ability; health services research tag; human subject; injury /disease stressor; interview; longitudinal human study; middle childhood (6-11); pain; parent offspring interaction; patient care management; pediatrics; personality; psychological stressor; psychosomatic disorders; relapse /recurrence; social competition; training

The career development and research plans outlined in this Mentored Patient-Oriented Research Career Development Award application are designed to enable the candidate to independently design and conduct studies of pediatric current abdominal pain (RAP), its course, and associated psychopathology relevant to the design of future clinical interventions. RAP is defined as at least three episodes of medically unexplained abdominal pain occurring over a period of at least three months that are severe enough to affect the activities of the child. RAP is common, impairing, and puts children at risk for dangerous, costly, and unnecessary medical procedures. Previous studies of RAP and associated psychopathology have not employed standardized psychiatric interviews and longitudinal designs, and are confounded by tertiary referral bias. Understanding the relationship of RAP and its course with anxiety, depression, and other risk factors will prepare the way for the development of effective intervention and prevention strategies, as well as family and psychobiological studies. The proposed study of RAP is the first to employ standardized psychiatric interviews and a longitudinal design in pediatric primary care, and will compare RAP presenters with unaffected children on measures of psychopathology, temperament, other somatic symptoms, life events, and parental psychopathology, health, and encouragement of illness behavior, providing the candidate experience in the conduct of longitudinal studies and the use of modern research assessments. The candidate is certified in pediatrics, psychiatry, and child and adolescent psychiatry, with nearly ten years of post-graduate clinical experience. Dr. David Brent will serve as preceptor. Course work and directed readings in epidemiology, biostatistics, data management, research ethics, the neurobiology of brain-gut interactions, neuropharmacology, drug development, and the design of psychopharmacologic and psychotherapeutic clinical trials will complement the research training.

本指导性患者导向研究职业发展奖申请中概述的职业发展和研究计划旨在使候选人能够独立设计和开展儿科当前腹痛 (RAP)、其病程以及与设计相关的相关精神病理学研究。未来的临床干预。 RAP 的定义是在至少三个月内发生至少 3 次医学上无法解释的腹痛，且严重程度足以影响儿童的活动。 RAP 很常见，会损害儿童，并使儿童面临危险、昂贵和不必要的医疗程序的风险。 之前对 RAP 和相关精神病理学的研究没有采用标准化的精神病学访谈和纵向设计，并且受到三级转诊偏倚的困扰。 了解 RAP 及其病程与焦虑、抑郁和其他危险因素的关系将为制定有效的干预和预防策略以及家庭和心理生物学研究铺平道路。 拟议的 RAP 研究是第一个在儿科初级保健中采用标准化精神病学访谈和纵向设计的研究，并将比较 RAP 演示者与未受影响的儿童的精神病理学、气质、其他躯体症状、生活事件以及父母精神病理学、健康、鼓励患病行为，为候选人提供进行纵向研究和使用现代研究评估的经验。 该候选人拥有儿科、精神病学以及儿童和青少年精神病学方面的认证，拥有近十年的研究生临床经验。 大卫·布伦特博士将担任导师。 流行病学、生物统计学、数据管理、研究伦理、脑肠相互作用的神经生物学、神经药理学、药物开发以及精神药理学和心理治疗临床试验的设计等方面的课程作业和定向阅读将补充研究培训。