PREVALENCE AND PROGRESSION OF DM2 RISK IN MA YOUTH

MA 青年中 DM2 风险的患病率和进展

• 批准号: 6635343
• 负责人: DANIEL ESTEN HALE
• 金额: $ 32.63万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6635343
• 关键词: Hispanic Americans; acanthosis nigricans; adolescence (12-20); blood tests; child physical development; clinical research; comorbidity; disease /disorder proneness /risk; fasting; gender difference; glucose; glucose tolerance test; high risk behavior /lifestyle; homeostasis; human subject; hyperinsulinism; insulin; interview; longitudinal human study; middle childhood (6-11); noninsulin dependent diabetes mellitus; pathologic process; pediatrics; questionnaires; statistics /biometry

Over the past 5 years there have been reports of type 2 diabetes (DM2) in minority children in the U.S., including Mexican Americans (MA). Locally, in the past 3 years more MA children were seen with DM2 than type 1 diabetes (DM1), although the incidence of DM1 has not decreased. While the high prevalence and rising incidence of DM2, related risk factors and co-morbidities in MA adults is extensively documented, minimal information is available on the prevalence or incidence of these problems in MA children who share the same genetic heritage and live in the same environment. Even less is known about the natural progression from genetic risk to overt disease in children. Therefore, the specific aims of this proposal are to: 1. Determine the prevalence of risk factors, hyperinsulinism, impaired fasting glucose and diabetes in a homogenous group of approximately 2000 MA children 4th grade, 9 and 10 years of age) (Phase 1) 2. Explore the relationship between risk factors and glucose homeostasis abnormalities in approximately 300 MA children using a detailed clinical assessment and extensive biochemical investigations. The children will be in 3 subsets: impaired fasting glucose, high-risk, and low risk. (Phase 2). 3. Examine the temporal change in physical and biochemical parameters in the 3 subsets over 4-years (Phase 3). Children will be seen annually, because this is a period of dynamic physical change. Completion of the proposed studies will provide an estimate of the prevalence of glucose homeostasis abnormalities in MA children, increase understanding of the metabolic abnormalities at a relatively early age and stage, permit an examination of the natural progression of these abnormalities, and provide an assessment of the applicability of the new American Diabetes Association guidelines for screening MA children.

过去 5 年里，有报道称美国少数民族儿童（包括墨西哥裔美国人 (MA)）患有 2 型糖尿病 (DM2)。 在本地，过去3年，患有DM2的MA儿童比患有1型糖尿病(DM1)的MA儿童多，但DM1的发病率并未下降。 虽然 MA 成人中 DM2 的高患病率和发病率上升、相关危险因素和合并症有大量记录，但关于具有相同遗传遗传和生活在同一环境中的 MA 儿童中这些问题的患病率或发病率的信息很少。环境。 人们对儿童从遗传风险到明显疾病的自然进展知之甚少。 因此，本提案的具体目标是： 1. 确定大约 2000 名 4 年级、9 岁和 10 岁 MA 儿童的同质群体中危险因素、高胰岛素血症、空腹血糖受损和糖尿病的患病率（第一阶段） 2. 通过详细的临床评估和广泛的生化研究，探索大约 300 名 MA 儿童的危险因素与葡萄糖稳态异常之间的关系。 这些儿童将分为 3 个亚组：空腹血糖受损、高风险和低风险。 （第二阶段）。 3. 检查 4 年内 3 个子集的物理和生化参数的时间变化（第 3 阶段）。 每年都会见到孩子，因为这是一个身体动态变化的时期。完成拟议的研究将提供对 MA 儿童葡萄糖稳态异常患病率的估计，增加对相对较早年龄和阶段代谢异常的了解，允许检查这些异常的自然进展，并提供评估美国糖尿病协会新指南对 MA 儿童筛查的适用性。