EXTRAMURAL RESEARCH FACILITIEIS CONSTRUCTION

校外研究设施建设

基本信息

批准号：
6361124
负责人：
John R Raymond
金额：
$ 200万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-02-01 至 2007-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6361124
关键词：
EXTRAMURAL RESEARCH FACILITIEIS CONSTRUCTION

项目摘要

DESCRIPTION (provided by applicant): This application requests $2 million from National Center for Research Resources (NCRR) to fit-out shell space on the seventh floor of the BSB Addition, and to upgrade sanitization and related support facilities in the existing BSB seventh floor animal facility, creating a state-of-the-art horizontally integrated rodent facility. The long-term objective is to expand MUSC's capacity for development and utilization of genetically engineered mouse models of human disease in national priority areas. Specific Aims are: 1) to provide state-of-the-art rodent facilities conducive to increasing interaction, efficiency and productivity among investigators by centralizing the program for transgenic animals; 2) to provide five new animal holding suites and a transgenic laboratory suite in an AAALAC-accreditable animal facility with BSL2 capability; and 3) to renovate the existing BSB cage wash and autoclave area. The beneficiaries are MUSC faculty members in five different basic science departments who are conducting, cutting-edge research funded by 13 different institutes of the National Institutes of Health (NIH). The grant will make it possible to facilitate recruitment of additional NIH-funded investigators who rely on animal models; remove constraints from present NIH-funded investigators who currently must design their experiments and methodology around available resources; accelerate the career development of junior investigators; improve research training opportunities for graduate students and postdoctoral fellows; make MUSC more competitive for institutional training grants by virtue of increased quality of faculty and trainees; and maintain accreditations for laboratory animal facilities. Total project cost is $4,212,617, of which the University's share is 53 percent.

描述（由申请人提供）：本申请要求 200 万美元从国家研究资源中心 (NCRR) 到装修外壳空间七楼BSB加建，并升级卫生及相关现有 BSB 七楼动物设施的支持设施，创造最先进的水平综合啮齿动物设施。长期来看目标是扩大 MUSC 的开发和利用能力人类疾病的基因工程小鼠模型是国家优先重点地区。具体目标是：1）提供最先进的啮齿动物设施有利于增加相互之间的互动、效率和生产力研究人员通过集中转基因动物项目； 2）到提供五个新的动物饲养室和一个转基因实验室套房具有 BSL2 能力的 AAALAC 认证动物设施； 3）翻新现有的 BSB 笼清洗和高压灭菌区域。受益人是 MUSC 五个不同基础科学领域的教职人员正在进行尖端研究的部门由 13 个不同的机构资助美国国立卫生研究院 (NIH) 的研究所。这笔补助金将使其实现可能有助于招募更多由 NIH 资助的研究人员依赖动物模型；消除目前 NIH 资助的限制目前必须设计实验和方法的研究人员围绕可用资源；加速青少年职业发展调查员；改善研究生的研究培训机会和博士后研究员；使 MUSC 更具机构竞争力通过提高教师和学员的质量而提供培训补助金；和维持实验动物设施的认证。项目总成本是4,212,617美元，其中大学的份额为53%。

项目成果

期刊论文数量（161）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans.

葡萄糖神经酰胺合酶是新型隐球菌致病性的重要调节因子。

DOI：
发表时间：
2006-06
期刊：
影响因子：
0
作者：
Rittershaus, Philipp C;Kechichian, Talar B;Allegood, Jeremy C;Merrill Jr, Alfred H;Hennig, Mirko;Luberto, Chiara;Del Poeta, Maurizio
通讯作者：
Del Poeta, Maurizio

The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system.

隐球菌酶肌醇磷酸鞘脂-磷脂酶 C 赋予巨噬细胞抗真菌作用的抵抗力，并促进真菌传播到中枢神经系统。