RES ANIMAL FACIL: ANTIPSYCHOTIC DRUG

RES 动物设施：抗精神病药物

• 批准号: 6794353
• 负责人: DONALD E WILSON
• 金额: $ 29.13万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794353
• 关键词: animal colony; antipsychotic agents; behavioral genetics; biomedical facility; building /facility design /renovation; psychiatry; schizophrenia; university

DESCRIPTION (provided by applicant): Funds ($1,165,000) are requested to fit-out a newly constructed animal facility at the MPRC, the research arm of the Department of Psychiatry of the University of Maryland School of Medicine. An internationally renowned center for schizophrenia research, the MPRC was built in 1968 on the grounds of the Spring Grove State Psychiatric Hospital in Catonsville, Maryland. Designed to understand the neurobiological basis of schizophrenia and to provide patients with the newest possible treatment options, the MPRC is currently home to more than 20 highly interactive, National Institutes of Health (NIH)-funded pre-clinical and clinical investigators, and 180 support personnel. Laboratory-based scientists use an unsatisfactory animal facility on the fourth floor of the MPRC. The proposed 7,291 sq. ft. state-of-the-art vivarium will occupy space in a new addition adjacent to the MPRC main building and will replace the antiquated and grossly inadequate animal quarters. The new facility, projected for completion in February 2003, will be indispensable for fulfilling current application obligations and will allow MPRC scientists to maintain their competitive edge in future applications for federal and nonfederal support. In particular, the vivarium will create an opportunity for MPRC investigators to accommodate and use genetically manipulated animals, and, thus, to partake in the revolution in psychiatric genetics. Availability of such animals in close proximity to the MPRC laboratories is critically important for the successful continuation of translational research within the Institution and beyond. The proposed project, which will be co-financed by an $1,165,000 contribution from the State of Maryland, is therefore, considered instrumental for sustaining the stature of the MPRC in schizophrenia researc

描述（由申请人提供）：需要资金（1,165,000 美元）在 MPRC（马里兰大学医学院精神病学系的研究机构）内装修新建的动物设施。 MPRC 是国际知名的精神分裂症研究中心，于 1968 年在马里兰州卡顿斯维尔的斯普林格罗夫州立精神病医院内建立。 MPRC 旨在了解精神分裂症的神经生物学基础，并为患者提供最新的治疗选择，目前拥有 20 多名高度互动、由美国国立卫生研究院 (NIH) 资助的临床前和临床研究人员以及 180 名支持人员人员。实验室科学家使用 MPRC 四楼的一个不令人满意的动物设施。拟议的 7,291 平方英尺最先进的动物园将占据 MPRC 主楼附近的新扩建空间，并将取代陈旧且严重不足的动物宿舍。新设施预计于 2003 年 2 月竣工，对于履行当前的申请义务是不可或缺的，并将使 MPRC 科学家能够在未来申请联邦和非联邦支持时保持竞争优势。特别是，动物园将为 MPRC 研究人员创造一个容纳和使用基因改造动物的机会，从而参与精神遗传学的革命。在 MPRC 实验室附近提供此类动物对于在机构内外成功开展转化研究至关重要。因此，拟议的项目将由马里兰州 1,165,000 美元的捐款共同资助，被认为有助于维持 MPRC 在精神分裂症研究中的地位。