LUNG IMAGING: MRI OF HYPERPOLARIZED NOBLE GASES

肺部成像：超极化稀有气体 MRI

• 批准号: 6657646
• 负责人: IVAN E DIMITROV
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657646
• 关键词: alternative medicine; bioimaging /biomedical imaging; biomedical resource; liver; magnetic resonance imaging; medical rehabilitation related tag; nervous system; pain; rehabilitation; skeletal system; technology /technique

This study is an exploration of the human brain processing of pain using functional MRI on humans. The goal is to develop objective quantitative assay of pain. The subjects will be patients with a specific type of pain, postherpetic neuralgia, an aftermath of herpes zoster. Such patients have pain is localized to the nerve affected by the herpes zoster and is always unilateral. The severity of the pain increases greatly when the localized area of the nerve is touched with external stimuli such as brushing. We will examine brain activation pattern in response to painful stimulation. Stimulation on contralateral non-painful site will be used as control. Normal subjects will also serve as controls. A stimulating apparatus for use in magnet bore has been constructed, which allows a mechanical stimulus on patient body surface area with a controlled amount of force. We are starting to collect data with the exerted force varied, and oberve the change in intensity in the brain images.

这项研究是对疼痛的人脑处理的探索 在人类上使用功能性MRI。 目标是发展目标 疼痛的定量测定法。 受试者将是患者 特定类型的疼痛，后骨神经痛，疱疹的后果 带状管。 这样的患者的疼痛位于受影响的神经 疱疹带领始终是单方面的。 疼痛的严重程度 当神经的局部区域与 外部刺激，例如刷牙。 我们将检查大脑激活 响应疼痛刺激的模式。 刺激 对侧非抚养部位将用作对照。 普通的 受试者也将充当控制。 用于磁铁孔中的刺激设备已有 构建，这允许对患者身体进行机械刺激 表面积具有控制力量。 我们开始 收集具有施加力的数据各不相同，并改变了变化 大脑图像中的强度。