MODELING OF NEUTROPHIL MOTILITY

中性粒细胞运动建模

• 批准号: 6611241
• 负责人: THOMAS Duane COATES
• 金额: $ 15.58万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6611241
• 关键词: bioengineering /biomedical engineering; biomedical resource; cardiovascular system; health care; surgery; technology /technique

The aim of this project it to investigate the fundamental time-resolved fluorescence processes induced by excimer lasers in order to develop quantitative criteria for reliable tissue characterization. Our approach involves time-resolved laser-induced fluorescence measurements for the purpose of identification of spectro-temporal patterns characteristic of different fluorophores, which can be used as "signatures" for unique and unambiguous characterization of various fluorophores (collagen, elastin, NAD and NADH). During this grant year, we developed a novel methodology/technology of laser-induced fluorescence attenuation using multiple optic fibers as a means of reliable on-line measurements of ischemia and hypoxia. The initial results have demonstrated the feasibility of such measurements, creating the prospect of useful applications in many surgical and diagnostic procedures.

该项目的目的是调查基本 准分子激光器诱导的时间分辨荧光过程 为了制定可靠组织的定量标准 表征。 我们的方法涉及时间分辨激光诱导的 荧光测量目的 不同荧光团特征的光谱周期模式， 可以用作独特和明确的“签名” 各种荧光团的表征（胶原蛋白，弹性蛋白，NAD和NAD和 纳德）。 在这个赠款的一年中，我们开发了一本小说 使用激光诱导的荧光衰减的方法/技术 多个光纤作为可靠的在线测量的手段 缺血和缺氧。 最初的结果证明了 这种测量的可行性，创造了有用的前景 在许多手术和诊断程序中的应用。