Changes in anesthetic requirements after spinalization

脊柱化术后麻醉要求的变化

• 批准号: 6626204
• 负责人: STEVEN L JINKS
• 金额: $ 4.64万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6626204
• 关键词: anesthesia; anesthetics; autonomic reflex; blood pressure; dizocilpine; dorsal horn; dosage; electrophysiology; excitatory aminoacid; inhibitor /antagonist; isoflurane; laboratory rat; limb movement; pain; postdoctoral investigator; psychomotor function; spinal cord injury; spinal reflex; stimulus /response; sympathetic nervous system

Reorganization of spinal circuitry and removal of supraspinal influences after spinal cord injury (SCI) result in pathophysiologic conditions, such as motor and autonomic hyperflexia (AH) in response to noxious stimuli. Individuals with SCI are thus at increased risk during surgical procedures and require special anesthetic management, but few studies that have addressed this problem. An animal model to assess changes in anesthetic effects on spinal reflexes following SCI would aid in developing effective anesthetic management of the SCI population. Changes in anesthetic (isoflurane) effects on motor and sympathetic reflex pathways after acute and chronic spinalization, and the effects of NMDA antagonists on these changes, will be investigated in rats. These will be studied using quantitative measurement of responses evoked by noxious stimuli (pinch, heat), including limb movement, blood pressure, and electrophysiological recording of single dorsal horn neurons, along with simultaneous recording of sympathetic and motor nerve activity. Changes in isoflurane dose-response functions for these parameters., and correlations among them, will be determined before and after acute (complete and partial) and chronic spinalization. Thus, these studies aim to determine how and where changes in spinal reflex pathways occur after SCI, and how they relate to anesthetic requirements. This knowledge will lead to safer anesthesia in SCI patients, and to a better understanding of nociceptive/spinal reflex pathways occur after SCI, and how they relate to anesthetic requirements. This knowledge will lead to safer anesthesia in SCI patients, and to a better understanding of nociceptive/spinal reflex pathways, their supraspinal control, and changes in spinal circuitry following SCI.

脊髓损伤（SCI）（SCI）后脊柱回路的重组并去除脊髓骨上的影响会导致病理生理状况，例如运动和自主性超屈服（AH），以响应有害刺激。因此，患有SCI的个体在手术程序中的风险增加，需要特殊的麻醉管理，但是很少有解决此问题的研究。一种动物模型评估SCI后脊柱反射的麻醉作用变化的动物模型将有助于开发SCI种群的有效麻醉管理。急性和慢性脊柱化后麻醉（异氟烷）对运动和交感反射途径的作用的变化，NMDA拮抗剂对这些变化的影响将在大鼠中研究。这些将通过定量测量有害刺激（捏，热）引起的反应进行研究，包括肢体运动，血压和单背角神经元的电生理记录，以及同时记录交感神经和运动神经活性。这些参数的异氟烷剂量响应函数的变化将在急性（完整，部分）和慢性脊柱化之前和之后确定它们之间的相关性。因此，这些研究旨在确定SCI后脊柱反射途径的变化以及与麻醉需求之间的关系。这些知识将导致SCI患者的麻醉更安全，并更好地了解SCI后发生伤害性/脊髓反射途径，以及它们与麻醉需求的关系。这些知识将导致SCI患者的麻醉更安全，并更好地了解伤害性/脊柱反射途径，其上脊髓控制以及SCI后脊柱回路的变化。