Physical Activity on Insulin Resistance in the Elderly

体力活动对老年人胰岛素抵抗的影响

基本信息

批准号：
6649672
负责人：
WIlliam J Evans
金额：
$ 21.06万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2005-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6649672
关键词：
aerobic exercise aging clinical research glucose metabolism hormone regulation /control mechanism human old age (65+) human subject insulin insulin sensitivity /resistance

项目摘要

DESCRIPTION: (provided by applicant) Advancing age is associated with insulin resistance, glucose intolerance, and Type 2 diabetes. Regular higher-intensity aerobic exercise reduces insulin resistance and lowers the risk of Type 2 diabetes. Nonetheless, recent cross-sectional data, based on ACSM/CDC physical activity recommendations for moderate-intensity activity on most if not all days of the week (i.e., 1000 kcal/wk), demonstrate that insulin levels are lower with regular moderate-intensity activity in middle-aged adults, suggesting a reduction in insulin resistance. Despite these cross-sectional data, few well-controlled prospective studies have determined if these recommendations are appropriate to reduce insulin resistance in the elderly. Because higher-intensity aerobic exercise is not practical for a large percentage of the elderly, data are needed to determine the efficacy of moderate-intensity exercise on reducing insulin resistance. Therefore, the primary aim of this study will be to examine the influence of 1000 kcal/wk of moderate versus higher-intensity aerobic exercise on insulin-simulated glucose disposal. A secondary aim will examine if moderate and higher-intensity aerobic exercise differentially influence non-exercising activity. Recent data in the elderly suggest that regular higher-intensity activities may reduce non-exercising activity during rest of the day. We will recruit 57, 65-90 y old women and men, who will be randomized into one of the following three groups: 1) Moderate-intensity activity (1000 kcal/wk at 50 percent VO2peak; 2) Higher-intensity activity (1000 kcal/wk at 75 percent VO2peak); 3) Control. Subjects will complete 12 wk of aerobic cycling with pre and post-testing for insulin-stimulated glucose disposal via the hyperinsulinemic/euglycemic clamp, glucose tolerance by an OGTT, and body composition using dual energy x-ray absorptiometry. Physical activity levels will be assessed by structured questionnaire every 3 weeks. Our primary hypothesize is that 1000 kcal/wk of moderate or higher-intensity activity will be equally effective decreasing insulin resistance in the elderly. Our secondary hypothesis is that higher-intensity activity will decrease non-exercising physical activity in the elderly. This New Investigator application will provide data to base future aerobic exercise recommendations in elderly adults.

描述：（由申请人提供）促进年龄与胰岛素有关电阻，葡萄糖不耐症和2型糖尿病。常规的高强度有氧运动降低了胰岛素抵抗并降低了2型的风险糖尿病。但是，基于ACSM/CDC物理的最近的横截面数据在大多数（如果不是全部）（如果不是全部）上的中等强度活动的活动建议一周中的天数（即1000 kcal/wk），证明胰岛素水平为在中年成年人中具有常规中等强度活性的较低表明胰岛素耐药性降低。尽管有这些横截面数据，很少有控制的前瞻性研究确定这些是否是否建议适合降低老年人的胰岛素抵抗。因为高强度有氧运动对于大型运动不实用老年人的百分比需要数据来确定减少胰岛素抵抗的中等强度运动。因此，这项研究的主要目的是检查1000 kcal/wk的影响胰岛素模拟的葡萄糖上的中度与高强度有氧运动处理。次要目标将检查中等强度和高强度有氧运动行使差异化影响非行动活动。最新数据老年人表明，常规的高强度活动可能会减少在一天的其余时间内进行非行进活动。我们将招募57、65-90岁男女，将被随机分为以下三组之一： 1）中等强度的活动（50％vo2peak时1000 kcal/wk； 2）更高强度的活性（vo2peak时为1000 kcal/wk）； 3）控制。受试者将在预测试前后完成12周的有氧循环。胰岛素刺激的葡萄糖处置通过高胰岛素/葡萄糖夹，使用双能X射线的OGTT和身体组成的葡萄糖耐受性吸收法。体育锻炼水平将通过结构化评估问卷每3周一次。我们的主要假设是1000 kcal/wk的中等或更高强度的活动将同样有效降低老年人的胰岛素抵抗。我们的次要假设是更高强度的活动将降低非行动的体育活动老年。这个新的研究者应用程序将为未来提供数据老年人的有氧运动建议。