TREATMENT OF BRAIN TUMORS WITH 2-5A-ANTITELOMERASE RNA

用 2-5A-抗端粒酶 RNA 治疗脑肿瘤

• 批准号: 6342144
• 负责人: SEIJI KONDO
• 金额: $ 24.75万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6342144
• 关键词: DNA replication; antisense nucleic acid; apoptosis; athymic mouse; cis platinum compound; combination cancer therapy; complementary RNA; cyclin dependent kinase; cytotoxicity; disease /disorder model; drug screening /evaluation; endoribonucleases; enzyme activity; enzyme inhibitors; gene targeting; glioma; histopathology; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplastic cell; nonhuman therapy evaluation; oligonucleotides; pharmacokinetics; telomerase; tissue /cell culture

项目成果

Down-regulation of telomerase activity in malignant glioma cells by p27KIP1.

p27KIP1 下调恶性胶质瘤细胞中的端粒酶活性。

• 发表时间: 2003-12
• 作者: Kanzawa, Takao;Komata, Tadashi;Kyo, Satoru;Germano, Isabelle M;Kondo, Yasuko;Kondo, Seiji
• 通讯作者: Kondo, Seiji

Combination therapy of 2-5A antisense against telomerase RNA and cisplatin for malignant gliomas.

抗端粒酶 RNA 2-5A 反义和顺铂联合治疗恶性胶质瘤。

• 发表时间: 2001-06
• 影响因子: 5.2
• 作者: Kondo, Y;Komata, T;Kondo, S
• 通讯作者: Kondo, S

Telomerase as a therapeutic target for malignant gliomas.

端粒酶作为恶性胶质瘤的治疗靶点。

• 发表时间: 2002-01-21
• 作者: Komata, Tadashi;Kanzawa, Takao;Kondo, Yasuko;Kondo, Seiji
• 通讯作者: Kondo, Seiji

Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component.

用 2-5A-抗端粒酶 RNA 成分在体外和体内治疗前列腺癌。

• 发表时间: 2000-04-27
• 作者: Kondo, Y;Koga, S;Komata, T;Kondo, S
• 通讯作者: Kondo, S

2-5A antisense telomerase RNA therapy for intracranial malignant gliomas.

2-5A反义端粒酶RNA治疗颅内恶性神经胶质瘤。

• 发表时间: 2000-08-15
• 作者: Mukai, S;Kondo, Y;Koga, S;Komata, T;Barna, B P;Kondo, S
• 通讯作者: Kondo, S