Clinical Center: Parkinson's Disease Neuroprotection

临床中心：帕金森病神经保护

• 批准号: 6661884
• 负责人: JAY S SCHNEIDER
• 金额: $ 11.98万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6661884
• 关键词: Parkinson's disease; chemoprevention; clinical research; cooperative study; experimental designs; human subject; human therapy evaluation; medical outreach /case finding; nervous system disorder chemotherapy; neuroprotectants; patient oriented research

DESCRIPTION (provided by applicant): The objective of this project is to perform pilot studies to identify putative neuroprotective agents for Parkinson's disease and to demonstrate convincingly in a randomized, double-blind clinical trial the efficacy of one or more pharmacological agents for slowing the progression of Parkinson's disease and to determine the toxicity and tolerability of these agents.Our Clinical Research Center will be a consortium of three local sites, each with a history and interest in conducting Parkinson's disease clinical trials. The lead site will be Thomas Jefferson University (Parkinson's Disease Research Unit), with satellite sites at Main Line Health Hospitals in Bryn Mawr, PA and Neurology Associates, P.A. in Wilmington, DE. This consortium, spanning the Philadelphia metropolitan area, the heavily populated northwestern suburbs of Philadelphia, Southeast Pennsylvania, Southern New Jersey and the entire state of Delaware will greatly enhance our ability to enroll patients in any research project in which we participate. The strength of this consortium is the collective research expertise of the participants and the resultant enhanced availability of early Parkinson's disease patients. As a result of this consortium, we are confident that we will be able to exceed the minimum number of patients to be recruited into study by approximately 50%. Each component of this Clinical Center is staffed by clinical personnel experienced in the clinical and research assessment of Parkinson's disease patients and by accomplished nurses and clinical coordinators with experience in the recruitment and retention of Parkinson's disease patients and the administration of clinical protocols.

描述（由申请人提供）：该项目的目的是进行试点研究，以确定帕金森病的假定神经保护剂，并在随机、双盲临床试验中令人信服地证明一种或多种药物减缓进展的功效帕金森病的研究，并确定这些药物的毒性和耐受性。我们的临床研究中心将是由三个当地站点组成的联合体，每个站点都有进行帕金森病临床的历史和兴趣试验。主要站点将是托马斯·杰斐逊大学（帕金森病研究中心），卫星站点位于宾夕法尼亚州布林莫尔的 Main Line Health 医院和宾夕法尼亚州神经病学协会。在特拉华州威尔明顿。这个联盟横跨费城大都市区、费城人口稠密的西北郊区、宾夕法尼亚州东南部、新泽西州南部和整个特拉华州，将大大增强我们在我们参与的任何研究项目中招募患者的能力。该联盟的优势在于参与者的集体研究专业知识以及由此提高的早期帕金森病患者的可用性。通过这个联盟，我们有信心能够比招募参与研究的最低患者人数多出约 50%。该临床中心的每个组成部分均由在帕金森病患者临床和研究评估方面经验丰富的临床人员以及在招募和保留帕金森病患者以及临床方案管理方面经验丰富的护士和临床协调员组成。