UCSF CC/SFSU Collaborative--Cancer Research and Training

UCSF CC/SFSU 合作--癌症研究和培训

• 批准号: 6515106
• 负责人: JOHN A WATSON
• 金额: $ 7.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515106
• 关键词: fungal genetics; vertebrate embryology

This Collaborative is between the University of California, San Francisco Cancer Center (UCSFCC) and San Francisco State University (SFSU). It will initiate two pilot Research Projects and two Planning and Development activities for collaborative undergraduate and/or pre- doctoral research training in cancer biology. The collaborative pilot Research Projects will involve two teams of SFSU/UCSFCC investigators; both collaborations will consist of a newly hired SFSU. Assistant Professor of Biology and a senior UCSF faculty member who is also a member of the UCSFCC. UCSF Professor Elizabeth Blackburn, Ph.D. will serve as mentor and co-investigator with Sally Pasion, Ph.D. to characterize telomere ends in fission yeast DNA replication and repair mutant. Wilfred Denetclaw, Ph.D. (appointment as a SFSU Assistant Professor of Biology effective September 2000) will be mentored by his former UCSF post-doctoral supervisor Professor Charles Ordahl. Their collaborative Research Project will focus on the biological markers for dermomyotomal myotome progenitor cells and their epithelial-to-mesenchymal transition into the myotome layer. The research questions and mentoring commitments built into each collaborative pilot Research project are designed to result in the submission of RO1 proposals during the third year of this P-20 planning grant. Student research training will be the focus for the Planning and Development section of this proposal. One pilot Planning and Development activity will use a joint SFSU and UCSFCC faculty committee to develop a more aggressive and concerted placement process/program to recruit SFSU undergraduate (MARC and MBRS- RISE) and SFSU MA/MS degree (NIH Bridge and MBRS-RISE) students into UCSFCC laboratories specifically will review and evaluate the past involvement of, 1) SFSU undergraduates (MARC and MBRS- RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU MA/MS degree students whose research was executed in UCSF faculty laboratories as a basis to develop an action plan that will provide an excellent training experience in an environment permeated with a cancer biology focus. The second pilot Planning and Development activity will be directed at doing the ground work necessary to develop a joint R-25E or R-25T or T- 32 pre-doctoral training proposal during the third year of this P-20 project. Realization of this goal will require serious planning through joint UCSFCC-SFSU faculty meetings and retreats to 1) identify and prioritize short and long-term pre-doctoral student cancer research training goals and 2) develop a mutually acceptable collaborative pre- doctoral cancer research training program within the guidelines of a R- 25E or R-25T or T-32 funding mechanism. A core element of any final proposal will be the application of recruitment and retention strategies that will result in an increased enrollment of under-represented strategies that will result in an increased enrollment of under-represented minorities into and graduation from Ph.D. programs.

该合作由加州大学旧金山癌症中心 (UCSFCC) 和旧金山州立大学 (SFSU) 合作开展。它将启动两个试点研究项目和两项规划和开发活动，以进行癌症生物学本科生和/或博士前合作研究培训。合作试点研究项目将涉及两个由 SFSU/UCSFCC 研究人员组成的团队；这两项合作都将由新聘用的 SFSU 组成。生物学助理教授，加州大学旧金山分校 (UCSF) 资深教员，也是加州大学旧金山分校 (UCSFCC) 成员。加州大学旧金山分校教授伊丽莎白·布莱克本博士将与 Sally Pasion 博士一起担任导师和联合研究员。表征裂殖酵母 DNA 复制和修复突变体中的端粒末端。威尔弗雷德·丹尼克劳博士（被任命为 SFSU 生物学助理教授，2000 年 9 月生效）将接受他的前 UCSF 博士后导师 Charles Ordahl 教授的指导。他们的合作研究项目将重点关注真皮肌节肌节祖细胞的生物标记及其向肌节层的上皮间质转化。每个协作试点研究项目中内置的研究问题和指导承诺旨在导致在 P-20 规划拨款的第三年提交 RO1 提案。学生研究培训将是本提案规划和发展部分的重点。一项试点规划和发展活动将利用 SFSU 和 UCSFCC 联合教员委员会制定更积极和协调一致的安置流程/计划，以招收 SFSU 本科生（MARC 和 MBRS-RISE）和 SFSU 硕士/硕士学位（NIH Bridge 和 MBRS-RISE） ) 进入 UCSFCC 实验室的学生将专门回顾和评估过去参与的 1) SFSU 本科生（MARC 和 MBRS-RISE）在 UCSF 暑期研究经历和 2) 学年论文研究SFSU RISE 的经验）在 UCSF 暑期研究经验和 2） SFSU 硕士/硕士学位学生的学年论文研究经验，其研究是在 UCSF 教员实验室进行的，作为制定行动计划的基础，该计划将提供出色的培训经验充满癌症生物学焦点的环境。第二个试点规划和开发活动将旨在开展必要的基础工作，以便在 P-20 项目的第三年期间制定联合 R-25E 或 R-25T 或 T-32 博士前培训提案。要实现这一目标，需要通过 UCSFCC-SFSU 联合教师会议和务虚会进行认真规划，以 1) 确定短期和长期博士前癌症研究培训目标并确定优先顺序，2) 制定双方都能接受的协作博士前癌症研究培训R-25E 或 R-25T 或 T-32 资助机制指导方针内的计划。任何最终提案的核心要素将是应用招募和保留战略，这将导致代表性不足的战略的入学人数增加，从而导致代表性不足的少数群体的博士入学率和毕业率增加。程序。