Neural mechanisms of size and shape perception in somatosensory cortex

体感皮层大小和形状感知的神经机制

• 批准号: 6595036
• 负责人: STEVEN S HSIAO
• 金额: $ 15.58万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6595036
• 关键词: Macaca mulatta; afferent nerve; behavioral /social science research tag; electronic recording system; fingers; form /pattern perception; hand; microelectrodes; neural information processing; orientation; proprioception /kinesthesia; psychophysics; sensory mechanism; sensory signal detection; size perception; somesthetic sensory cortex; stimulus /response; touch

Funds are requested to study the neural mechanisms underlying three- dimensional (3D) shape and size perception in somatosensory system. While the perception of local surface features is based on the activity in the mechanoreceptive afferents innervating the skin, gross object features such as shape and size are based on hand and finger position and cutaneous information from multiple points of contact with the object. Project 1 concentrates on how information is integrated from the multiple points of contact; This project (3) concentrates on the role of hand and finger position in 3D form processing. The aim is to study how information from tactile and proprioceptors within and between digits are integrated in SI and SII cortex of the awake monkey to provide information about the 3D shape and size of objects. Aim 1 is to investigate the processing of shape information by studying the integration of tactile information across adjacent digits positioned at different combinations of flexion, simulating contact with objects with varying shapes. Aim 2 is to investigate the processing of information about object size by studying how digit spread affects the responses of somatosensory neurons to local patents of stimulation. Two modes of stimulation, active and passive, will be used. In the passive mode stimuli that are or are not consistent with a single curved surface (aim 1) or stimulate an object of a specified size (aim 2) will be applied to the hand while the animal performs a tactile match-to-sample task. In the active mode, the animal actively moves it fingers to contact the stimuli that vary in curvature and size. In this manner we will study neuronal response tuning for object size and shape in various areas in the somatosensory cortex and determine and whether the tuning differs during active and passive touch.

要求资金研究体感系统中三维（3D）形状和大小感知的基础神经机制。虽然对局部表面特征的感知基于支配皮肤的机械感受传入的活性，但诸如形状和大小之类的总物体特征基于手指的位置和手指位置以及从与物体的多个接触点上的皮肤信息。项目1集中​​于如何从多个接触点集成信息；该项目（3）集中在3D形式处理中的手和手指位置的作用上。目的是研究醒目猴子的SI和SII皮层中如何将来自触觉的信息和数字之间的触觉信息的信息集成在一起，以提供有关对象的3D形状和大小的信息。目的1是通过研究位于屈曲不同组合的相邻数字的触觉信息的整合，研究形状信息的处理，模拟与形状不同的物体的接触。 AIM 2是通过研究数字扩散如何影响体感神经元对局部刺激专利的反应来研究有关对象大小的信息的处理。将使用两种主动和被动的刺激模式。在被动模式刺激中，或与单个弯曲表面不一致（AIM 1）或刺激指定尺寸的对象（AIM 2）时，将在动物执行触觉匹配样本的任务时将其应用于手。在活动模式下，动物会积极移动手指，以接触曲率和大小变化的刺激。通过这种方式，我们将研究体感皮质中各个区域的物体大小和形状的神经元反应调整，并确定在主动和被动触摸过程中调整是否有所不同。