LONGITUDINAL STUDIES OF ALZHEIMERS DISEASE AND SIVD

阿尔茨海默病和 SIVD 的纵向研究

• 批准号: 6596373
• 负责人: DAN M. MUNGAS
• 金额: $ 26.84万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6596373
• 关键词: Alzheimer's disease; brain mapping; brain subcortex; cerebral ischemia /hypoxia; clinical research; cognition disorders; dementia; hippocampus; human data; longitudinal human study; multiinfarct dementia; myelinopathy; neuropathology; pathologic process

The purpose of this project will be to better characterize independent and interactive contributions to dementia of AD and SIVD. This project will use common, core data that is available for all subjects enrolled in the overall program project grant (PPG). It will focus on global and specific cognitive abilities and independent functioning as dependent variables and will incorporate date from longitudinal follow-up and neuropathology to address questions about additive and interactive effects of AD and SIVD in determining presentation and progression of dementia. It will develop linear measurement procedures that will be implemented within the Central Coordinating Core and will serve as the basis for evaluating effects of AD and SIVD on progression of dementia. Mechanisms of cognitive and functional change in AD and SIVD will be examined using cross sectional, longitudinal, and pathological data. Multiple replications will be accomplished by performing the same analyses using data from three sources so that convergence of findings can be directly compared. The availability of data from neuropathology will allow for a critical form of replication. Hypotheses to be tested in this project are: 1) Cognitive and functional impairment in SIVD and AD are primarily due to loss of volume of cortical gray matter and hippocampus, 1a) Effects of lacunar infarcts and abnormal white matter on cognitive and functional impairment are primarily mediated by associated loss of volume of cortical gray matter and hippocampus, 2) Predicted relationships from Hypothesis 1 will be supported in neuropathology diagnosed cases without AD and independently in pathology diagnosed cases with AD, 3) Rate of progression of cognitive impairment and dementia will be primarily determined by the rate of change in volume of cortical gray matter and hippocampus and 4) Specific cognitive abilities will be differentially predicted by localized brain changes.

该项目的目的是更好地表征对AD和SIVD痴呆症的独立和互动贡献。该项目将使用通用的核心数据，可用于全面计划项目赠款（PPG）的所有受试者。它将侧重于全球和特定的认知能力以及独立发挥作用作为因变量，并将纵向随访和神经病理学的日期纳入有关AD和SIVD添加性和交互作用的问题，以确定痴呆症的表现和进展。它将开发线性测量程序，该程序将在中央协调核心内实施，并将作为评估AD和SIVD对痴呆进展的影响的基础。将使用横截面，纵向和病理数据检查AD和SIVD认知和功能变化的机制。通过使用来自三个来源的数据进行相同的分析来完成多种复制，以便可以直接比较发现的收敛性。来自神经病理学的数据的可用性将允许复制的关键形式。在该项目中要测试的假设是：1）SIVD和AD中的认知和功能障碍是由于皮质灰质和海马体积损失的损失，1A）腔体梗塞的影响，主要是对认知和函数障碍的影响，主要是由皮质灰质的损失介导的。神经病理学诊断为没有AD的病例，并且在诊断为AD的病理病例中独立于病理学，3）认知障碍和痴呆症的进展率将主要取决于皮质灰质和海马的变化率，以及4）特定的认知能力将由局部大脑变化差异预测。