Impact of Trauma of Terroist Attack on Bipolar Patients

恐怖袭击造成的创伤对双相情感障碍患者的影响

• 批准号: 6640442
• 负责人: MARK H POLLACK
• 金额: --
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-24 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640442
• 关键词: adolescence (12-20); adult human (21+); anxiety; behavioral /social science research tag; bipolar depression; clinical research; depression; disasters; disease /disorder proneness /risk; human subject; longitudinal human study; mental health epidemiology; pathologic process; posttraumatic stress disorder; psychological shock; psychological stressor; questionnaires; sleep disorders; social support network; substance abuse related disorder; violence

The terrorist attacks of September 11, 2001, provide a tragic but unique opportunity to study risk factors for the emergence of PTSD symptoms in vulnerable individuals as a result of significant but indirect trauma. The research literature has begun to characterize many of the individual vulnerability and environmental factors for the emergence of PTSD. However, information on these putative vulnerability factors is limited by the general unavailability of pre-trauma variables in affected individuals. In addition, much of the available information is specific to the emergence of PTSD resulting from the direct exposure to a trauma. We propose to examine this issue with a study to be embedded within the ongoing evaluation of an outpatient population of bipolar patients, the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). STEP-BD is a multi-center, longitudinal study that provides an unprecedented opportunity to examine the emergence and consequences of PTSD and associated symptoms following the September 11th attacks. STEP-BD offers to the study of PTSD the rare opportunity to use a large data set that richly characterizes the functioning of a vulnerable population prior to the onset of trauma, and has in place a study team and procedures for monitoring the psychiatric outcomes for these individuals over time. Accordingly, we are proposing additional assessment protocols to allow analysis of the impact of indirect exposure to the September 11th attacks, on 260 individuals at two of the largest STEP sites. By collecting information on the symptomatic response to the September 11th attacks, this proposed study can provide an especially comprehensive assessment of pre- event risk factors for PTSD in response to a uniform stressor and its effects on the subsequent course of illness.

2001 年 9 月 11 日的恐怖袭击提供了一个悲惨但独特的机会来研究易受伤害的个体由于重大但间接的创伤而出现 PTSD 症状的风险因素。 研究文献已经开始描述导致 PTSD 出现的许多个人脆弱性和环境因素。 然而，有关这些假定的脆弱因素的信息受到受影响个体创伤前变量普遍不可用的限制。 此外，许多现有信息都是针对直接遭受创伤而导致的创伤后应激障碍（PTSD）的出现。 我们建议通过一项研究来检验这个问题，该研究将嵌入对双相情感障碍门诊患者群体的持续评估中，即双相情感障碍系统治疗强化计划（STEP-BD）。 STEP-BD 是一项多中心纵向研究，为检查 9 月 11 日袭击后 PTSD 的出现和后果以及相关症状提供了前所未有的机会。 STEP-BD 为 PTSD 的研究提供了难得的机会，可以使用大量数据集，该数据集丰富地描述了弱势群体在创伤发生之前的功能，并建立了一个研究团队和程序来监测这些群体的精神结果。个人随着时间的推移。 因此，我们提出额外的评估协议，以分析间接暴露于 9 月 11 日攻击对两个最大的 STEP 站点的 260 人的影响。 通过收集 9 月 11 日袭击的症状反应信息，这项拟议的研究可以对 PTSD 事件前的危险因素进行特别全面的评估，以应对统一的压力源及其对随后病程的影响。