PARAMAGNETIC OXYGEN SENSITIVE MATERIALS TO ASSESS TUMOR PO2 AT MULTIPLE SITES

顺磁性氧敏感材料评估肿瘤多个部位的 PO2

• 批准号: 6353180
• 负责人: JULIA A O'HARA
• 金额: $ 0.61万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6353180
• 关键词: Mammalia; bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource; building /facility design /renovation; gas; nuclear magnetic resonance spectroscopy

BOLD imaging has been used to monitor oxygenation in brain by capitalizing on the fact that deoxyhemoglobin has a paramagnetic susceptability and so changes in deoxyhemoglobin content can be visualized using MR imaging. This phenomenon forms the core of the field of cognative, or functional MR imaging. In addition, this measurement provides a rapid, spatially selective method of assessing the brain's response to acute hypoxia. We are investigating the relationships between changes in deoxyhemoglobin using BOLD imaging and brain pO2 using EPR oximetry. The relationships between tissue pO2 values and averaged hemoglobin saturation are not easily predicted and must be measured. With the combination of "non-invasive" EPR oximetry and MR imaging, we hope to calibrate the BOLD response in living brain, determine the regional senstivity of brain to functional imaging and identify spatial heterogeneity in the brain's response to acute hypoxia.

BOLD 成像已被用于监测大脑中的氧合 利用脱氧血红蛋白具有顺磁性的事实 易感性等脱氧血红蛋白含量的变化可以 使用 MR 成像进行可视化。 这种现象形成了核心 认知或功能性 MR 成像领域。 此外，这 测量提供了一种快速的、空间选择性的评估方法 大脑对急性缺氧的反应。 我们正在调查 使用 BOLD 成像脱氧血红蛋白变化之间的关系 使用 EPR 血氧测定法测量脑氧分压 (pO2)。 组织之间的关系 pO2 值和平均血红蛋白饱和度不容易预测 并且必须进行测量。 与“非侵入式”EPR相结合 血氧测定法和 MR 成像，我们希望校准 BOLD 响应 活体大脑，确定大脑对功能的区域敏感性 成像并识别大脑反应的空间异质性 急性缺氧。