ELECTROPHYSIOLOGY

电生理学

• 批准号: 6651208
• 负责人: George Fein
• 金额: $ 24.29万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651208
• 关键词: AIDS /HIV neuropathy; HIV infections; alcoholic beverage consumption; alcoholism /alcohol abuse; brain electrical activity; clinical research; dosage; electroencephalography; evoked potentials; human morbidity; human subject; intercellular connection; longitudinal human study; neural information processing; neurotoxicology; pathologic process; stimulus /response

The primary goal of this project is to determine the effect of chronic heavy alcohol use on event-related potential and EEG coherence measures on functional CNS morbidity of HIV disease. Chronic heavy alcohol use may affect HIV CNS effects on treatment seeking and treatment adherence) or result in a reduced treatment response which would cause increased CNS morbidity. It can also have direct and specific effects on the CNS independent of the progression of the overall HIV disease process. Both of these mechanisms and their effect will be evaluated in a cross-sectional study of HIV+ and HIV- chronic heavy drinkers and light/non-drinkers with longitudinal follow-up at two years. Our synergistic model of HIV infection and alcohol use predicts that the CNS morbidity in individuals who are HIV+ and are chronic heavy alcohol users will be greater than the sum of that in individuals who are HIV+ light/non-drinkers and that in individuals who are HIV-chronic heavy drinkers. We hypothesize that this synergy will occur as a result of behavioral effects of heavy alcohol use on treatment seeking, treatment adherence, nutrition, or risk behaviors (which could lead to repeated inoculations with new viral strains) or biological effects of heavy alcohol user (e.g., possible effects on the metabolism and bioavailability of treatment medications). We will: (1) determine whether chronic heavy alcohol using HIV+ individuals have greater CNS morbidity as measured by electrophysiological testing than do light/non-drinking HIV+ individuals, 92) determine whether HIV+ heavy drinking individuals' CNS morbidity as measured by electrophysiological testing has a greater rate of progression or a lesser treatment response compared to HIV+ light/non-drinking individuals, (3) determine whether the effects of chronic heavy alcohol use and HIV infection on electrophysiological measurements of CNS morbidity at baseline and over the follow-up period are additive or, exceeding additive effects, (4) within the context of the Program Project Grant, test hypotheses both about the mechanisms underlying CNS information processing disabilities and about the impact of these disabilities of clinically important outcomes. We will recruit and study four groups of subjects: 120 chronic heavy alcohol drinking HIV+ individuals, 120 light/non-drinking HIV+ individuals, 60 chronic heavy drinking HIV-individuals, and 60 light/non- drinking HIV-individuals. We will examine the integrity and speed of various information processing operations involving cortico-cortical and subcortical-cortical connections and/or cortical/subcortical regions. Information processing abilities will be assess by electroencephalographic (EEG) measures of cortical connectivity and event-related potential (ERP) indices of the activation of semantic networks and of the brain's orienting response to novel stimuli.

该项目的主要目标是确定慢性病的影响 大量饮酒对事件相关电位的影响和脑电图一致性测量 HIV 疾病的功能性中枢神经系统发病率。长期大量饮酒可能会 影响 HIV 中枢神经系统对治疗寻求和治疗依从性的影响）或 导致治疗反应降低，从而导致中枢神经系统增加 发病率。它还可以对中枢神经系统产生直接和特定的影响 独立于整个艾滋病毒疾病过程的进展。两者都 这些机制及其效果将在横截面中进行评估 对 HIV+ 和 HIV- 长期大量饮酒者和少量/不饮酒者的研究 两年纵向随访。我们的艾滋病毒协同模型 感染和饮酒可预测个体的中枢神经系统发病率 艾滋病病毒感染者和长期酗酒者将比 HIV+ 轻度/不饮酒者和 HIV 阳性个体的总和 长期酗酒的艾滋病毒携带者。我们假设这 大量饮酒的行为效应会产生协同作用 关于治疗寻求、治疗依从性、营养或危险行为 （这可能导致重复接种新病毒株）或 酗酒者的生物效应（例如，可能对身体产生影响） 治疗药物的代谢和生物利用度）。 我们将： (1) 确定长期酗酒是否使用 HIV+ 根据电生理学测量，个体的中枢神经系统发病率更高 测试比轻度/不饮酒的 HIV+ 个体进行测试，92）确定是否 HIV+ 酗酒者的中枢神经系统发病率 电生理测试的进展速度较大或较小 与 HIV+ 轻度/不饮酒个体相比的治疗反应，(3) 确定长期大量饮酒和艾滋病毒的影响是否 感染对中枢神经系统发病率电生理测量的影响 基线和随访期间是累加的，或者超过累加的 (4) 在计划项目拨款范围内，测试 关于中枢神经系统信息处理机制的假设 残疾以及这些残疾对临床的影响 重要成果。 我们将招募并研究四组受试者： 120 名慢性重度 饮酒 HIV+ 个体，120 轻度/不饮酒 HIV+ 个人、60 名长期酗酒的艾滋病毒感染者和 60 名轻度/非艾滋病毒感染者 饮酒艾滋病毒的人。我们将检查完整性和速度 涉及皮质-皮质的各种信息处理操作 皮质下-皮质连接和/或皮质/皮质下区域。 通过脑电图评估信息处理能力 (EEG) 皮质连接和事件相关电位 (ERP) 测量 语义网络和大脑的激活指数 定向对新刺激的反应。