ELECTROPHYSIOLOGY

电生理学

• 批准号: 6651208
• 负责人: George Fein
• 金额: $ 24.29万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651208
• 关键词: AIDS /HIV neuropathy; HIV infections; alcoholic beverage consumption; alcoholism /alcohol abuse; brain electrical activity; clinical research; dosage; electroencephalography; evoked potentials; human morbidity; human subject; intercellular connection; longitudinal human study; neural information processing; neurotoxicology; pathologic process; stimulus /response

The primary goal of this project is to determine the effect of chronic heavy alcohol use on event-related potential and EEG coherence measures on functional CNS morbidity of HIV disease. Chronic heavy alcohol use may affect HIV CNS effects on treatment seeking and treatment adherence) or result in a reduced treatment response which would cause increased CNS morbidity. It can also have direct and specific effects on the CNS independent of the progression of the overall HIV disease process. Both of these mechanisms and their effect will be evaluated in a cross-sectional study of HIV+ and HIV- chronic heavy drinkers and light/non-drinkers with longitudinal follow-up at two years. Our synergistic model of HIV infection and alcohol use predicts that the CNS morbidity in individuals who are HIV+ and are chronic heavy alcohol users will be greater than the sum of that in individuals who are HIV+ light/non-drinkers and that in individuals who are HIV-chronic heavy drinkers. We hypothesize that this synergy will occur as a result of behavioral effects of heavy alcohol use on treatment seeking, treatment adherence, nutrition, or risk behaviors (which could lead to repeated inoculations with new viral strains) or biological effects of heavy alcohol user (e.g., possible effects on the metabolism and bioavailability of treatment medications). We will: (1) determine whether chronic heavy alcohol using HIV+ individuals have greater CNS morbidity as measured by electrophysiological testing than do light/non-drinking HIV+ individuals, 92) determine whether HIV+ heavy drinking individuals' CNS morbidity as measured by electrophysiological testing has a greater rate of progression or a lesser treatment response compared to HIV+ light/non-drinking individuals, (3) determine whether the effects of chronic heavy alcohol use and HIV infection on electrophysiological measurements of CNS morbidity at baseline and over the follow-up period are additive or, exceeding additive effects, (4) within the context of the Program Project Grant, test hypotheses both about the mechanisms underlying CNS information processing disabilities and about the impact of these disabilities of clinically important outcomes. We will recruit and study four groups of subjects: 120 chronic heavy alcohol drinking HIV+ individuals, 120 light/non-drinking HIV+ individuals, 60 chronic heavy drinking HIV-individuals, and 60 light/non- drinking HIV-individuals. We will examine the integrity and speed of various information processing operations involving cortico-cortical and subcortical-cortical connections and/or cortical/subcortical regions. Information processing abilities will be assess by electroencephalographic (EEG) measures of cortical connectivity and event-related potential (ERP) indices of the activation of semantic networks and of the brain's orienting response to novel stimuli.

该项目的主要目标是确定慢性的影响 在事件相关的潜力和脑电图相干措施上大量使用酒精 HIV疾病的功能性中枢神经系统发病率。慢性大量饮酒可能 影响HIV CNS对寻求治疗和治疗依从性的影响）或 导致治疗反应减少，这会导致CNS增加 发病率。它也可以对中枢神经系统产生直接和特定的影响 独立于整体HIV疾病过程的进展。两个 这些机制及其效果将在横截面中评估 HIV+和HIV慢性饮酒者以及轻/非饮酒者的研究 两年的纵向随访。我们的艾滋病毒协同模型 感染和酒精使用预测个体中枢神经系统发病率 艾滋病毒+和慢性重酒精使用者将大于 在艾滋病毒+光/非饮酒者的个人中的总和 艾滋病毒饮酒者的人。我们假设这是 由于大量饮酒的行为影响，协同作用将发生 在寻求治疗，治疗依从性，营养或风险行为上 （这可能导致反复接种新病毒菌株）或 重酒精使用者的生物学影响（例如，可能影响 治疗药物的代谢和生物利用度）。 我们将：（1）确定是否使用HIV+慢性重酒精 通过电生理测量，个体具有更大的中枢神经系统发病率 测试比光/非饮用的艾滋病毒+个体，92）确定是否是否 艾滋病毒+大量饮酒个体的中枢神经系统发病率 电生理测试的进展率更高或较小 与HIV+光/非饮食个体相比，治疗反应，（3） 确定慢性大量饮酒和艾滋病毒的影响是否 CNS发病率的电生理测量的感染 基线和后续时间是添加剂或超过添加剂 效果，（4）在计划项目赠款的背景下测试 假设有关中枢神经系统信息处理的机制 残疾及其临床上这些残疾的影响 重要的结果。 我们将招募和研究四组受试者：120个慢性重型 饮酒艾滋病毒+个人，120光/非饮用的艾滋病毒+ 个人，60种慢性饮酒艾滋病毒个人，60个光/非 - 喝艾滋病毒个人。我们将研究的完整性和速度 各种信息处理操作涉及皮质皮质和 皮层皮层连接和/或皮质/皮层下区域。 信息处理能力将通过脑电图评估 （EEG）皮质连通性和事件相关电位（ERP）的度量 语义网络激活和大脑的激活索引 对新型刺激的定向反应。