TOBACCO RELATED MALIGNANCIES PROGRAM

烟草相关恶性肿瘤计划

• 批准号: 6664440
• 负责人: YORK E MILLER
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-06 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6664440
• 关键词: biological signal transduction; cancer prevention; chemical carcinogenesis; chemical related neoplasm /cancer; clinical research; diagnosis design /evaluation; digestive neoplasm; human subject; neoplasm /cancer diagnosis; neoplasm /cancer genetics; nicotine; respiratory neoplasm; tobacco abuse

Description: (Applicant's Description) The overall goal of the Tobacco Related Malignancies Program is to decrease the incidence, morbidity, and mortality of tobacco induced cancers of the aerodigestive tract. The Program is comprised of 28 investigators with interests in various aspects of carcinogenesis, genetics, cell signaling/biology, clinical trials and primary prevention/screening/early detection. The Program includes both basic and clinical scientists with complementary interests. Clinical specialities include Medical Oncology, Radiation Oncology, Pathology, Pulmonary Medicine, General Internal Medicine, Psychiatry, Immunology, Dentistry, Head and Neck and Thoracic Surgery. Interactions between members are promoted by a twice-monthly research seminar, day-long or half-day symposia and individual outside speakers. A weekly Pulmonary/Thoracic/Oncology multidisciplinary conference and a weekly Head and Neck Tumor conference promote the enrollment of patients onto therapeutic trials. A Career Development Program has been successful in supporting young faculty members who have gone on to careers in research related to tobacco induced cancer. A Developmental Program has supported pilot projects, several of which have subsequently resulted in independent funding. Several novel therapeutic strategies based on basic and preclinical work at our institution are now being translated to human trials, including one supported by an NCI RAID. In addition to individual research grants, interactions between program members have resulted in several multi-investigator proposals, including a Specialized Program of Research Excellence in Lung Cancer, Genetic Epidemiology of Lung Cancer Consortium, Lung Cancer Biomarkers and Chemoprevention Consortium, a Biomarkers Development Component of the Early Detection Research Network and an NCI/NIDA Transdisciplinary Tobacco Use Research Center; all but the last of these were fully funded. Several parts of the latter were funded as were several other tobacco projects described in the Clinical and Community Prevention and Control Programs.

描述：（申请人的描述）烟草的总体目标 相关恶性肿瘤计划旨在降低发病率、发病率和 烟草诱发呼吸消化道癌症的死亡率。该计划 由 28 名对各方面感兴趣的研究人员组成 致癌作用、遗传学、细胞信号传导/生物学、临床试验和原发性 预防/筛查/早期发现。该计划包括基本和 兴趣互补的临床科学家。临床专科 包括肿瘤内科、放射肿瘤学、病理学、肺科、 普通内科、精神病学、免疫学、牙科、头颈科 和胸外科。会员之间的互动是通过 每月两次的研究研讨会、一天或半天的研讨会和个人 外部扬声器。每周一次肺科/胸科/肿瘤科多学科 会议和每周一次的头颈肿瘤会议促进了注册 的患者进行治疗试验。职业发展计划已 成功地支持了在以下领域继续职业生涯的年轻教师 与烟草诱发癌症相关的研究。发展计划有 支持试点项目，其中一些项目随后取得了成果 独立资助。几种基于基础和治疗的新治疗策略 我们机构的临床前工作现在正在转化为人体试验， 包括 NCI RAID 支持的一种。除了个人研究 赠款、计划成员之间的互动已导致若干 多研究者提案，包括专门研究计划 肺癌卓越奖、肺癌遗传流行病学联盟、 肺癌生物标志物和化学预防联盟（生物标志物） 早期检测研究网络和 NCI/NIDA 的开发部分 跨学科烟草使用研究中心；除了最后一个之外的所有这些都是 资金充足。后者的几个部分以及其他几个部分都得到了资助 临床和社区预防中描述的烟草项目和 控制程序。