CELL BIOLOGY

细胞生物学

• 批准号: 6664433
• 负责人: KARL H PFENNINGER
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-06 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6664433
• 关键词: apoptosis; carcinogenesis; cell adhesion; cell biology; cell death; cell motility; cell proliferation; mass spectrometry; metastasis; neoplasm /cancer; neoplasm /cancer invasiveness; receptor binding

Description: (Applicant's Description) The scientific goals of the Cell Biology Program are 1) to understand the mechanisms of cell proliferation and cell death and of cancer development, progression, invasion and metastasis, and 2) to develop cancer intervention strategies based on this understanding. The Program endeavors to enhance infrastructure support for this research by providing seminars, core support and mentoring, by conducting recruitments, and by facilitating research collaborations. The Cell Biology Program's unifying research theme comprises the regulatory mechanisms involved in proliferation and apoptosis, membrane traffic and receptor recycling, cell surface interactions and motility, and their applications to cancer. There are three partially overlapping focus areas: "Proliferation and Apoptosis," "Host-Tumor Interactions," and "Membrane Traffic." The Program includes an outstanding signaling group with two HHMI investigators and a Jimmy V awardee, and it has generated numerous intra- and inter-program collaborations and several jointly held research grants. The 29 members of the Program have about $7.5 million in annual direct cost grant support. This includes 14 projects funded by the NCI and other cancer (peer-reviewed) agencies totaling over $900,000 in annual direct support, as well as several program project and other multi-member grants. The Program's activities include the establishment of a new seminar series, the organization of interdisciplinary basic-clinical minisymposia, the granting of pilot and postdoctoral development awards, the participation in core development (protein analysis, mass spectrometry, and cell imaging), and the recruitment of a new faculty member in the area of cell adhesion/motility/metastasis.

描述：（申请人的描述）细胞的科学目标 生物学计划是1）了解细胞增殖的机制和 细胞死亡以及癌症发育，进展，侵袭和转移， 2）基于这种理解制定癌症干预策略。 该计划努力通过通过 通过进行招聘，提供研讨会，核心支持和指导 并通过促进研究合作。细胞生物学计划的 统一研究主题包括涉及的监管机制 增殖和凋亡，膜流量和受体回收，细胞 表面相互作用和运动及其在癌症中的应用。有 三个部分重叠的重点区域：“增殖和凋亡”，， “宿主肿瘤互动”和“膜流量”。该程序包括 杰出信号小组与两个HHMI调查人员和一个Jimmy V获奖者， 它已经产生了许多跨编程和编程间的合作以及 一些共同持有的研究补助金。该计划的29名成员大约 750万美元的年度直接成本赠款支持。这包括14个项目 由NCI和其他癌症（同行评审）机构资助 $ 900,000的年度直接支持以及几个计划项目和 其他多成员的赠款。该计划的活动包括建立 一个新的研讨会系列，跨学科基础临床组织的组织 Minisymposia，授予飞行员和博士后发展奖， 参与核心发展（蛋白质分析，质谱和 细胞成像），以及在细胞区域招募新教师 粘附/运动/转移。