Breast Cancer Diagnosis with bFGF

使用 bFGF 诊断乳腺癌

• 批准号: 6613987
• 负责人: MAI BROOKS
• 金额: $ 2.66万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6613987
• 关键词: body fluids; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; diagnosis design /evaluation; early diagnosis; enzyme linked immunosorbent assay; female; fibroblast growth factor; hormone regulation /control mechanism; human subject; noninvasive diagnosis; oxytocin; women's health

DESCRIPTION: (Provided by applicant) Early detection of breast cancer has been shown to save lives. The process of angiogenesis plays a critical role in breast cancer growth and metastasis. Breast cancer cells are known to secrete potent angiogenic growth factors. The levels of these factors in the serum and urine of breast cancer patients have been shown to correlate with disease status, once the cancer has been diagnosed. We have observed that the levels of nipple fluid bFGF (basic fibroblast growth factor) are significantly elevated in breast cancer patients in comparison with those in controls. This proposal is a pilot study aimed at determining whether nipple fluid bFGF can be used as a diagnostic tool for breast cancer. Our belief is that the detection of nipple fluid bFGF could be complementary to the current methods used for breast cancer screening. Such a combination could potentially enhance our ability to detect breast cancer early, when it is still curable with existing treatment methods. The specific aims are as follows: 1) To improve the technique of breast nipple fluid aspiration; 2) To determine the validity of nipple fluid bFGF in diagnosing breast cancer in a specific population of patients; and 3) To compare nipple fluid bFGF with other diagnostic or screening tests for breast cancer.

描述：（由申请人提供）乳腺癌的早期检测已 显示可以拯救生命。血管生成过程起着至关重要的作用 乳腺癌的生长和转移。众所周知，乳腺癌细胞会分泌 强效血管生成生长因子。血清中这些因子的水平 乳腺癌患者的尿液已被证明与疾病相关 一旦癌症被诊断出来，状态。我们观察到， 乳头液 bFGF（碱性成纤维细胞生长因子）显着升高 乳腺癌患者与对照组相比。这个提议 是一项试点研究，旨在确定乳头液 bFGF 是否可以用作 乳腺癌的诊断工具。我们的信念是乳头的检测 液体 bFGF 可以补充目前用于乳腺癌治疗的方法 筛选。这种组合可能会增强我们检测的能力 乳腺癌早期，当它仍然可以用现有的治疗方法治愈时。 具体目标如下： 1）提高乳房乳头技术 液体抽吸； 2) 确定乳头液 bFGF 在治疗中的有效性 诊断特定患者群体的乳腺癌； 3) 至 将乳头液 bFGF 与其他乳房诊断或筛查测试进行比较 癌症。