HIV-related oral diseases among women in Harare

哈拉雷妇女与艾滋病毒相关的口腔疾病

• 批准号: 6553365
• 负责人: JOHN S GREENSPAN
• 金额: $ 3.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6553365
• 关键词: AIDS; Africa; HIV infections; biomarker; blood tests; clinical research; communicable disease control; female; helper T lymphocyte; human immunodeficiency virus; human subject; longitudinal human study; mouth; opportunistic infections; oral mucosa; pathologic process; public health; questionnaires

DESCRIPTION (provided by applicant): As part of the last competing renewal application of the parent program project P01-DE07946 (PI: John Greenspan), we sought to address emerging problems concerning the oral manifestations of HIV/AIDS. To date, our research has focused on HIV-infected populations in the US. However, we are proposing, as part of the present FIRCA application, to expand our study of the role and significance of oral manifestations of HIV infection to a setting that thus far has been understudied: sub-Saharan Africa. Because biologic assays to measure HIV disease progression are rarely accessible in sub-Saharan African countries due to prohibitive cost, other less expensive means of monitoring disease progression are needed. In US populations, visual inspection of the mouth and diagnosis of selected oral mucosal lesions have been found to be good predictors of HIV disease progression. If the predictive role of oral examination can be confirmed in sub-Saharan Africa, this would provide an important new tool for clinicians and public health specialists in this setting with respect to initiation of certain prophylactic drug regimens (such as tuberculosis or pneumocystis pneumonia prophylaxis) or anti-retrovirals. Midion Chidzonga, currently a Fogarty trainee supported by the "AIDS International Training and Research Program" Fogarty grant (2D43 TW00003-11; PI: Art Reingold; UCSF PI for the oral component in Zimbabwe: Caroline Shiboski) is conducting a cross-sectional study among HIV-infected and non-infected women in Zimbabwe to estimate oral mucosal disease prevalence in relation to HIV serostatus in this population. In collaboration with Dr. Chidzonga, we are hereby proposing to conduct a longitudinal study by expanding this ongoing cross-sectional study among Zimbabwean women. Our objectives are 1) to estimate oral mucosal disease incidence in relation to known immunologic marker of HIV disease progression (CD4 lymphocyte count); and 2) assess the sensitivity and specificity of detecting oral mucosal lesions by visual inspection of the mouth by trained nurses in a family planning/gynecology clinic in the sub-Saharan African setting. To address these objectives, we will conduct follow-up oral examinations at 6-month intervals on 225 HIV-positive participants who are being recruited into our cross-sectional study from an ongoing parent cohort study. Each participant would be seen at 6-month intervals over a 3-year period as part of the proposed study.

描述（由申请人提供）：作为父母计划项目P01-DE07946（PI：John Greenspan）的最后一次竞争续签应用的一部分，我们试图解决有关HIV/AIDS口服表现的新兴问题。迄今为止，我们的研究集中在美国的HIV感染人群上。但是，作为当前FIRCA应用的一部分，我们提议将我们对HIV感染的口服表现作用和意义的研究扩展到迄今已研究的环境：撒哈拉以南非洲。由于由于成本过高，撒哈拉以南非洲国家很少能够获得测量艾滋病毒疾病进展的生物学测定，因此需要其他较便宜的监测疾病进展的方法。在美国人群中，人们发现对口腔的视觉检查和诊断所选口腔粘膜病变的诊断是HIV疾病进展的良好预测指标。如果可以在撒哈拉以南非洲确认口腔检查的预测作用，那么在这种情况下，这将为临床医生和公共卫生专家提供重要的新工具，以启动某些预防性药物治疗疗法（例如结核病或肺类胸胸骨肺炎预防性肺炎）或抗逆转录病毒。 Midion Chidzonga目前是一名Fogarty培训生，由“ IADS国际培训和研究计划”支持Fogarty Grant（2d43 Tw00003-11; PI：Art Reingold; Art Reingold; Art Reingold; ucsf pi for Zimbabwe的口服组成部分：Caroline Shiboski中的caroline Shiboski中的杂种和杂种妇女之间的杂种妇女之间的杂物均在内。该人群中与HIV血清的患病率。通过与Chidzonga博士合作，我们在此提议通过扩大Zimbabwean妇女的持续横断研究来进行纵向研究。我们的目标是1）估计与已知的HIV疾病进展的免疫学标记有关的口腔粘膜疾病发病率（CD4淋巴细胞计数）； 2）通过在撒哈拉以南非洲地区的计划生育/妇科诊所中训练有素的护士对口腔的目视检查来评估口腔粘膜病变的敏感性和特异性。为了解决这些目标，我们将对225名HIV阳性参与者进行6个月间隔进行后续口试检查，这些参与者正在进行的一项父母同类研究中被招募到我们的横断面研究中。拟议的研究的一部分，将在3年的时间内以6个月的间隔看到每个参与者。