Acceptability of Spermicides Across Risk Groups and Time

不同风险群体和时间对杀精剂的可接受性

• 批准号: 6526441
• 负责人: HELEN P. KOO
• 金额: $ 48.01万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6526441
• 关键词: AIDS education /prevention; antiinfective agents; attitude; behavioral /social science research tag; clinical research; disease /disorder prevention /control; drug delivery systems; female; human subject; preference; sex behavior; sexually transmitted diseases; spermicide; women's health

We propose a three-year multidimensional project that includes a short-term, prospective study of women randomly assigned to two forms of spermicides (gel and suppository), and of women who participate and decline to participate in an STD clinical trial of a spermicidal gel. Prior to the randomized study, we will conduct qualitative research (N=216) to explore the factors related to choice and use of vaginal spermicides and microbicides, to identify the factors relevant to the choice of microbicides versus condoms or nonuse, and to help construct more valid instruments to be used in quantitative studies. The questionnaires will be used to measure the acceptability of vaginal microbicides and associated factors before women use their randomly assigned method and a month afterwards. We will enroll three groups whose future microbicide use could have major impact on the incidence of STDs: higher risk adult women from an STD clinic (N=460); lower risk adults from a public family planning clinic (N=460); and sexually active teenagers from both clinics (N=460). Comparing these groups on various acceptability measures and associated factors will give us a broader understanding of the likelihood of use in a larger at-risk population. The proposed research has six specific aims: To increase understanding of the factors affecting choice and use of methods, including vaginal gels and suppositories and condoms, to protect against STDs and HIV/AIDS; To develop better measures for studying acceptability of STD prevention methods and construct a more valid instrument for measuring acceptability; To measure the acceptability of vaginal spermicides (a gel and suppository) before use (t1) and after use (t2), compare their acceptability at both time points across the three risk groups, and examine change in acceptability after actual use; To determine whether the gel or suppository is the preferred delivery system for each of the three risk groups, using both attitudinal and behavioral measures; To investigate direct comparisons of the gel and suppository, and probe in-depth the reason for their likely use or nonuse; and , To determine the extent to which women participating in a typical STD clinical trial represent a broader population of potential microbicide users.

我们提出了一个为期三年的多维项目，其中包括对随机分配给两种形式的杀精子剂（凝胶和栓剂）的短期，前瞻性研究，以及参加并拒绝参加精子胶凝胶的性病临床试验的妇女。 在进行随机研究之前，我们将进行定性研究（n = 216），以探索与选择和使用阴道杀菌剂和微生物剂有关的因素，以确定与选择与霉菌剂相对于避孕套或不使用的因素，并帮助构建更有效的工具，以用于定量研究。 在妇女使用其随机分配的方法和一个月后，调查表将用于测量阴道菌皮和相关因素的可接受性。 我们将招募三个小组，他们的未来菌心使用可能会对性病的发病率产生重大影响：来自性病诊所的成年女性较高风险（n = 460）；公共计划生育诊所的降低风险成年人（n = 460）；以及两个诊所的性活跃青少年（n = 460）。 将这些群体在各种可接受性措施和相关因素上进行比较将使我们对在较大的高危人群中使用的可能性有更广泛的了解。拟议的研究具有六个具体的目的：提高对影响选择和使用方法的因素，包括阴道凝胶，栓剂和避孕套，以防止性病和艾滋病毒/艾滋病；制定更好的措施来研究预防性病预防方法的可接受性，并构建一种更有效的可接受性工具；要测量使用前（T1）和使用后（T2）的阴道杀菌剂（凝胶和栓剂）的可接受性，请在三个风险组中的两个时间点上比较它们的可接受性，并检查实际使用后的可接受性变化；确定凝胶或栓剂是使用态度和行为措施的三个风险组中的每个风险组的首选输送系统；研究凝胶和栓剂的直接比较，并深入探测其可能使用或不使用的原因；并且，为了确定参加典型的性病临床试验的妇女在多大程度上代表了更广泛的潜在菌心使用者。