ANALYSIS OF MOTOR SYSTEMS

电机系统分析

• 批准号: 6528507
• 负责人: TERRY J CROW
• 金额: $ 18.92万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528507
• 关键词: Mollusca; association learning; behavioral /social science research tag; cilium /flagellum motility; conditioning; electrostimulus; invertebrate locomotion; motor neurons; neural plasticity; photostimulus; stainings; synapses; voltage /patch clamp; Mollusca; association learning; behavioral /social science research tag; cilium /flagellum motility; conditioning; electrostimulus; invertebrate locomotion; motor neurons; neural plasticity; photostimulus; stainings; synapses; voltage /patch clamp

DESCRIPTION (Adapted from applicant's abstract): The long-term objective of this research project is to identify the neural circuit that is responsible for the generation of an example of muco-ciliary locomotion. The experiments proposed in this grant will provide insights into how a well defined neural circuit can be modified by a Pavlovian conditioning procedure to support the generation of a conditional response. To achieve these goals, a multi-disciplinary approach to the study of the cellular and synaptic basis of motor behavior will be carried out in the marine mollusc Hermissenda; a preparation that has proven useful in biophysical, biochemical, and molecular studies of learning. The research will use a combination of cellular neurophysiological and behavioral techniques to study ciliary locomotor behavior in intact animals and semi-intact preparations. One primary goal of the research is to identify the motor neurons that support the generation of ciliary movement. We will identify the neural elements of the central pattern generating network and determine how the properties of the network contribute to the locomotor program and the generation of ciliary locomotion. A second major goal is to determine how the circuit supporting locomotor behavior can be modulated by illumination and modified by an example of associative learning, Pavlovian conditioning. We will examine site of cellular and synaptic plasticity produced by Pavlovian conditioning in the network that is postsynaptic to the conditioned stimulus pathway. This experimental approach will expand our understanding of conditioning in Hermissenda by identifying other potential loci of plasticity produced by conditioning. These studies will help elucidate general principles underlying the organization of neural systems generating behavior and its modification by experience.

描述（根据申请人的摘要改编）： 该研究项目是确定负责的神经电路 为了生成粘膜运动的例子。 这 本赠款中提出的实验将提供有关如何井井有条的见解 可以通过Pavlovian调节程序来修改定义的神经回路 支持有条件响应的产生。 实现这些 目标，一种多学科的方法，用于研究细胞和 运动行为的突触基础将在海洋软体动物中进行 hermissenda;被证明在生物物理中有用的制剂， 生化和学习分子研究。 该研究将使用 细胞神经生理学和行为技术与 研究完整动物和半独立性的睫状运动行为 准备。 该研究的主要目标是识别电动机 支持睫状运动产生的神经元。 我们将确定 中央模式生成网络的神经元素并确定 网络的属性如何有助于运动计划和 睫状运动的产生。 第二个主要目标是确定 如何通过如何调制支撑运动行为的电路 帕夫洛维亚人的关联学习示例进行照明和修改 调理。 我们将检查细胞和突触可塑性的位置 由Pavlovian条件在网络中产生 条件刺激途径。 这种实验方法将扩大 我们通过识别其他 由调节产生的可塑性的潜在基因座。 这些研究会 帮助阐明神经组织的基础 系统生成行为及其通过经验进行修改。