Studies of a Neurohormonal Network Modulating Aggression

神经激素网络调节攻击性的研究

• 批准号: 6446410
• 负责人: ALO C BASU
• 金额: $ 2.39万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6446410
• 关键词: Malacostraca; aggression; ethology; hormone regulation /control mechanism; neurohormones; neurotransmitters; octopamine; oligopeptides; serotonin

DESCRIPTION (provided by applicant): An emergent theme in the study of aggression is that multiple hormonal and neuromodulatory systems influence behavioral output. However, mechanisms whereby these systems interact remain largely unknown. In Homarus americanus, the American lobster, a robust behavioral paradigm has been established for the quantification of aggression, and several neuromodulatory systems have been mapped. The fact that individual neurosecretory cells can be identified uniquely from animal to animal in this species will be exploited to uncover basic principles about regulation of co-transmitter release and interactions at the single-cell level between neurohormonal systems that modulate complex behaviors. The monoamines serotonin and octopamine and the pentapeptide proctolin have been implicated in the modulation of aggressive behavior in decapod crustaceans. These neuromodulatory systems converge at the second thoracic roots, nerve bundles which carry the prodigious neurosecretory endings of octopamine- and serotonin/proctolin-containing cells to the general circulation. Somata of neurons containing Crustacean Hyperglycemic Hormone (CHH), a putative stress hormone, are located at branch points in the second thoracic roots. This research proposal consists of experiments designed to examine the regulation of the CHH neurons by the other identified neurosecretory cells.

描述（申请人提供）：研究中的一个新兴主题 攻击性是多种激素和神经调节系统影响 行为输出。但是，这些系统相互作用的机制仍然存在 在很大程度上未知。在Americanus的Homarus Americanus中，美国龙虾，一个强大的 已经建立了行为范式来量化攻击性， 并且已经映射了几个神经调节系统。个人的事实 在此中，可以从动物到动物唯一地识别神经分泌细胞 物种将被利用以发现有关调节的基本原则 共递发送者释放和在单细胞水平的相互作用 调节复杂行为的神经激素系统。单胺5-羟色胺 章鱼胺和五肽Proctolin已与 decapod甲壳类动物中侵略性行为的调节。这些神经调节 系统收敛于第二个胸部根部，神经束，携带 章鱼胺和 含5-羟色胺/含有原血管素的细胞到一般循环。索马塔 含甲壳类高血糖激素（CHH）的神经元，一种推定的应激 激素位于第二个胸部根部的分支点。这 研究建议由旨在检查调节的实验组成 另一个鉴定出神经分泌细胞的CHH神经元。