Neuronal Basis of Conditioned Defeat

条件性失败的神经元基础

• 批准号: 6538370
• 负责人: Aaron M Jasnow
• 金额: $ 0.9万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6538370
• 关键词: amygdala; anxiety; behavior test; behavioral /social science research tag; coping; corticotropin releasing factor; excitatory aminoacid; fear; glutamates; hamsters; histology; hormone regulation /control mechanism; learned helplessness; locus coeruleus; mental disorders; microinjections; neuroanatomy; neurochemistry; neurophysiology; neuropsychology; neurotransmitter antagonist; psychological stressor; psychometrics; social adjustment; social behavior; thalamic nuclei

Many species experience social stressors during their lifetimes. This is especially true for humans, whose overwhelming source of conflict and stress is social in nature. A large body of evidence suggests that exposure to traumatic events or persistent high levels of stress are linked to the development and expression of a number of stress-related disorders (i.e. PTSD, depression, anxiety disorders). Animal models of stress-related disorders have provided important information about the neurobiological basis of many psychopathologies. Very few models, however, have examined these disorders in a biologically relevant paradigm. Conditioned defeat in Syrian hamsters provides an ideal model for studying the neurobiological basis of stress-related disorders in an ecologically relevant context. The goal of the current proposal is to explore the neuroanatomical and neurochemical basis of conditioned defeat by using site-specific microinjections into specific brain nuclei. The present proposal will test the hypothesis that the brain areas and neurochemicals that are involved in fear, anxiety and behavioral responses to stressors, in general, are also critical in the acquisition and expression of conditioned defeat. The results of the current proposal will provide important insight into the underlying physiological mechanisms of conditioned defeat. Additionally, these data will contribute to our knowledge about the neurobiological basis of human stress-related disorders.

许多物种在其一生中都会经历社会压力。对于人类来说尤其如此，其冲突和压力的压倒性来源本质上是社会性的。大量证据表明，遭受创伤性事件或持续的高压力与许多与压力相关的疾病（即创伤后应激障碍、抑郁症、焦虑症）的发展和表达有关。压力相关疾病的动物模型提供了有关许多精神病理学神经生物学基础的重要信息。然而，很少有模型在生物学相关的范式中检查这些疾病。叙利亚仓鼠的条件性失败为在生态相关背景下研究应激相关疾病的神经生物学基础提供了理想的模型。当前提案的目标是通过对特定脑核进行位点特异性显微注射来探索条件性失败的神经解剖学和神经化学基础。目前的提议将检验以下假设：一般来说，涉及恐惧、焦虑和对压力源的行为反应的大脑区域和神经化学物质对于条件性失败的获得和表达也至关重要。当前提案的结果将为了解条件性失败的潜在生理机制提供重要的见解。此外，这些数据将有助于我们了解人类压力相关疾病的神经生物学基础。