MINORITY PREDOCTORAL

少数族裔博士预科

• 批准号: 6529725
• 负责人: Ketema N Paul
• 金额: $ 3.54万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6529725
• 关键词: NMDA receptors; circadian rhythms; hamsters; hypothalamus; receptor; substance P; tachykinin

The primary objective of this research proposal is to characterize the role of NMDA, substance P, and the NK1 tachykinin receptor subtype in the generation and entrainment of circadian rhythms. The specific aims are to determine: 1) the extent that the tachykinin substance P induces or modulates phase shifts of SCN generated circadian rhythms, 2) the extent that the expression of the NK1 tachykinin receptor is necessary for the generation or entrainment of SCN generated circadian rhythms, and 3) the extent that the EAA receptor agonist NMDA can mimic the light induced suppression of nocturnal levels of pineal melatonin The studies will be performed using the Syrian hamster (Mesocricetus auratus). This animal model provides an advantage because it has a highly reproducible wheel-running rhythm and relatively high nocturnal levels of pineal melatonin. The results of the above studies will increase our understanding of the pharmacology of circadian entrainment, and may lead to the development of drugs to combat disorders of the circadian system.

这项研究建议的主要目的是表征NMDA，物质P和NK1速齿受体亚型在昼夜节律的产生和夹带中的作用。具体目的是确定：1​​）旋转基因P诱导或调节SCN产生的昼夜节律节奏的相移，2）NK1 tachykinin受体的表达对于SCN产生或夹带SCN产生的昼夜节律的范围以及3）EAA受体Agia anm anm anm anm anm anm anm scn产生或夹带所必需的程度。夜间松果褪黑激素的水平将使用叙利亚仓鼠（Mesocricetus auratus）进行研究。该动物模型提供了优势，因为它具有高度可再现的轮毂旋转节奏和夜间夜间松果褪黑激素水平的相对较高。以上研究的结果将增加我们对昼夜节律夹带药理学的理解，并可能导致药物发展以打击昼夜节律系统的疾病。