Racial Differences--Stress Induced Homeostatic Response

种族差异--压力诱导的稳态反应

• 批准号: 6434583
• 负责人: GREGORY ALAN HARSHFIELD
• 金额: $ 35.27万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-17 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6434583
• 关键词: African American; adolescence (12-20); albuminuria; aldosterone; angiotensin II; blood chemistry; blood pressure; cardiac output; caucasian American; clinical research; echocardiography; essential hypertension; excretion; hemodynamics; homeostasis; hormone regulation /control mechanism; norepinephrine; physiologic stressor; questionnaires; racial /ethnic difference; saluresis; statistics /biometry; stimulus /response; urinalysis; African American; adolescence (12-20); albuminuria; aldosterone; angiotensin II; blood chemistry; blood pressure; cardiac output; caucasian American; clinical research; echocardiography; essential hypertension; excretion; hemodynamics; homeostasis; hormone regulation /control mechanism; norepinephrine; physiologic stressor; questionnaires; racial /ethnic difference; saluresis; statistics /biometry; stimulus /response; urinalysis

The overall goal of this study is to obtain a more complete understanding of the role that physiologic changes induced by stress play in the development of ethnic differences in essential hypertension. The physiologic response to stress is a dynamic process. It includes the response to the stressor per se AND the physiologic response, which bring the body into homeostasis. The vast majority of research has focused on the physiologic response during stress while homeostatic changes following stress have largely been ignored. There is very little information about group differences. The general hypothesis of this proposal is as follows: African-Americans compared to Caucasians show slower natriuresis during and following the stress coupled with greater vasoconstriction. This will result in an extended period of elevated blood pressure following stress, exposing these individuals to an increased BP load, which leads to the premature development of end organ changes. Therefore, the aims of this study are: 1) contrast hemodynamic regulation in African-American and Caucasian subjects before, during, and two hours following a 60 minute stress period; 2) contrast hormonal regulation in African-American and Caucasian subjects during the procedure; 3) contrast levels of Na+ handling between African-American and Caucasian subjects during the procedure; 4) determine the relationship between measures of target organ change and BP changes during the recovery period. The proposed study will add considerably to the minimal knowledge of the factors underlying, and significance of, an impaired homeostatic process by a) for the first time identifying hormonal mechanism associated with the response; and b) for the first time determining the clinical significance of the response by relating it to target organ changes.

这项研究的总体目的是更完整地了解由压力发挥在基本高血压中种族差异发展中引起的生理变化的作用。 对压力的生理反应是一个动态过程。 它包括对压力源本身的反应和生理反应，这些反应将身体带入体内平衡。 绝大多数研究都集中在压力期间的生理反应上，而压力后的稳态变化在很大程度上被忽略了。 关于群体差异的信息很少。 该提议的总体假设如下：与高加索人相比，非裔美国人在压力期间和之后的纳特里雷氏菌相比较慢，并结合更大的血管收缩。 这将导致压力后长期升高的血压升高，使这些人承受增加的BP负荷，从而导致最终器官变化的过早发展。因此，这项研究的目的是：1）在60分钟的压力期之后，期间，期间和两个小时之前，在非裔美国人和高加索受试者中进行对比的血液动力学调节； 2）在手术过程中，非裔美国人和高加索受试者的对比激素调节； 3）在手术过程中，非裔美国人和高加索受试者之间的Na+处理水平； 4）确定恢复期间目标器官变化与BP变化的措施之间的关系。拟议的研究将大大增加对稳态过程受损过程的最低知识和意义，而a）首次确定与反应相关的激素机制； b）首次通过将响应与靶向器官变化相关联来确定响应的临床意义。