APOA-I Primary Sequence in HDL Assembly and Function

HDL 组装和功能中的 APOA-I 主要序列

• 批准号: 6537236
• 负责人: TRUDY M FORTE
• 金额: $ 35.6万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537236
• 关键词: animal genetic material tag; apolipoproteins; atherosclerosis; blood lipoprotein biosynthesis; cholesterol; disulfide bond; gene mutation; genetically modified animals; high density lipoproteins; human genetic material tag; laboratory mouse; macrophage; nutrition related tag; pathogenic diet; protein structure function

项目成果

Targeted replacement of mouse apolipoprotein A-I with human ApoA-I or the mutant ApoA-IMilano. Evidence of APOA-IM impaired hepatic secretion.

用人 ApoA-I 或突变体 ApoA-IMilano 靶向替代小鼠载脂蛋白 A-I。

• DOI: 10.1074/jbc.m207335200
• 发表时间: 2003
• 期刊: The Journal of biological chemistry
• 作者: Parolini,Cinzia;Chiesa,Giulia;Zhu,Yiwen;Forte,Trudy;Caligari,Silvia;Gianazza,Elisabetta;Sacco,MariaGrazia;Sirtori,CesareR;Rubin,EdwardM
• 通讯作者: Rubin,EdwardM

Cysteine substitutions in apolipoprotein A-I primary structure modulate paraoxonase activity.

• DOI: 10.1021/bi001922h
• 发表时间: 2001-01
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: Michael N. Oda;J. Bielicki;T. Berger;Trudy M. Forte