Immunity in healthy and neoplastic gut mucosa

健康和肿瘤性肠粘膜的免疫力

• 批准号: 6552410
• 负责人: Khashayarsha Khazaie
• 金额: $ 5.44万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-12 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6552410
• 关键词: T cell receptor; T lymphocyte; antigens; biological models; gastrointestinal epithelium; genetically modified animals; hemagglutinin; immune tolerance /unresponsiveness; immunity; immunoregulation; intestinal mucosa; intestine neoplasm; laboratory mouse; model design /development; neoplasm /cancer immunology; neoplastic cell; neoplastic growth; polymerase chain reaction; receptor expression; thymus

DESCRIPTION (provided by the applicant): To develop and use an animal model for studying immune responses to antigen expressed in healthy and neoplastic intestine, addressing: 1) The role of thymus in tolerance of gut specific antigens and the generation of regulatory T cells (Treg), 2) The role of encounter of antigen in the periphery on the maturation and survival of Treg, 3) The immunologic consequences of delayed as compared with constitutive gut specific expression of antigen, 4) The influence of tumor growth on immune responses and tolerance.

DESCRIPTION (provided by the applicant): To develop and use an animal model for studying immune responses to antigen expressed in healthy and neoplastic intestine, addressing: 1) The role of thymus in tolerance of gut specific antigens and the generation of regulatory T cells (Treg), 2) The role of encounter of antigen in the periphery on the maturation and survival of Treg, 3) The immunologic consequences of delayed as与抗原的本构肠型特异性表达相比，4）肿瘤生长对免疫反应和耐受性的影响。